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United States

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製品番号: HY-163315

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YPLP

YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2414391-44-7
分子式: C₂₅H₃₆N₄O₆
分子量:488.58

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

YPLP 構造式

CAS 番号: 2414391-44-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

AMPK アイソフォーム固有の製品をすべて表示 :

体内実験

YPLP (10-50 mg/kg, i.g. for 4 weeks) alleviates exhaustive exercise caused oxidative damage by decreasing lipid oxidation and increasing antioxidant enzyme activities in muscle tissues through Nrf2/Keap1 pathway^[1].
YPLP (10-50 mg/kg, i.g. for 4 weeks) improves ATP levels and energy metabolism through phosphorylation of AMPK and promotion of AMPK proteins in fatigue ICR mice^[1].
YPLP (10-50 mg/kg, i.g. for 4 weeks) regulates expressions of differential abundance proteins (DAPs), participates in the protein biosynthesis/degradation, muscle dynamics, and nuclear transport process to regulate muscle function in fatigue mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice^[1]
Dosage:

10-50 mg/kg/d
Administration:

i.g. for 4 weeks
Result:

Increased levels of Nrf2, ATP, pAMPK and decreased levels of Keap1.

化学情報

CAS 番号 2414391-44-7
分子量 488.58
分子式 C₂₅H₃₆N₄O₆
配列

Tyr-Pro-Leu-Pro
シーケンスの短縮

YPLP
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Cai J, et al., Studying Antifatigue Mechanism of Tyr-Pro-Leu-Pro in Exercise Mice Using Label-Free Proteomics. J Agric Food Chem. 2024 Jan 31;72(4):2178-2192. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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