YUKA1
Based on 1 publication(s) in Google Scholar
YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM. YUKA1 has less inhibitory active on KDM5C (IC50 = 7.12 μM) and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 can increase H3K4me3 levels and inhibit cell proliferation. YUKA1 can be used for the research of cancer, such as lung and breast cancers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.15%
- CAS 番号: 708991-09-7
- 分子式: C13H16N4O2S
- 分子量:292.36
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Epigenetics Compound Library
HY-L005
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Cancer Metabolism Compound Library
HY-L083
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Transcription Factor-Targeted Library
HY-L090
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Methylation Compound Library
HY-L203
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
MedChemExpress（MCE）の使用を引用している文献 YUKA1
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生物活性
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KDM5A 2.66 μM (IC50) |
KDM5C 7.12 μM (IC50) |
YUKA1 (50-100 μM, 48 h) increased H3K4me2 and H3K4me1 levels in HeLa and ZR-75-1 cells[1].
YUKA1 (25-100 μM, 3 days) inhibits proliferation in HeLa cells[1].
YUKA1 (50-100 μM, 2 weeks) reduces numbers of colonies in HeLa cells[1].
YUKA1 (100 μM, 35 days) reduces numbers of colonies companied with Trastuzumab (HY-P9907) in BT474 cells[1].
YUKA1 (100 μM, 35 days) reduces numbers of colonies companied with Gefitinib (HY-50895) in PC9 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:50 and 100 μM
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Incubation Time:48 h
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Result:Increased H3K4me2 and H3K4me1 levels.
化学情報
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CAS 番号 708991-09-7
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性状 Solid
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分子量 292.36
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分子式 C13H16N4O2S
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Color White to off-white
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SMILES
C=CCOC1=C(CNN2C(NN=C2)=S)C=CC=C1OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : 100 mg/mL (342.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4204 mL | 17.1022 mL | 34.2044 mL | 85.5110 mL |
| 5 mM | 0.6841 mL | 3.4204 mL | 6.8409 mL | 17.1022 mL | |
| 10 mM | 0.3420 mL | 1.7102 mL | 3.4204 mL | 8.5511 mL | |
| 15 mM | 0.2280 mL | 1.1401 mL | 2.2803 mL | 5.7007 mL | |
| 20 mM | 0.1710 mL | 0.8551 mL | 1.7102 mL | 4.2756 mL | |
| 25 mM | 0.1368 mL | 0.6841 mL | 1.3682 mL | 3.4204 mL | |
| 30 mM | 0.1140 mL | 0.5701 mL | 1.1401 mL | 2.8504 mL | |
| 40 mM | 0.0855 mL | 0.4276 mL | 0.8551 mL | 2.1378 mL | |
| 50 mM | 0.0684 mL | 0.3420 mL | 0.6841 mL | 1.7102 mL | |
| 60 mM | 0.0570 mL | 0.2850 mL | 0.5701 mL | 1.4252 mL | |
| 80 mM | 0.0428 mL | 0.2138 mL | 0.4276 mL | 1.0689 mL | |
| 100 mM | 0.0342 mL | 0.1710 mL | 0.3420 mL | 0.8551 mL |
YUKA1 関連分類
HY-100764 関連分類
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