KR-27452

Cat. No.: HY-179469: Data Sheet Handling Instructions
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KR-27452 is a selective and orally active PI4KIIIβ inhibitor with an IC₅₀ of 0.026 μM, while showing no activity against PI4KIIIα (IC₅₀ >10 μM) . KR-27452 specifically binds to and inhibits PI4KIIIβ, leading to reduced viral replication in cells. KR-27452 exhibits strong antiviral activity against human rhinovirus (RVs) and Coxsackievirus (COXs). KR-27452 can be used for the research of infection.

For research use only. We do not sell to patients.

KR-27452 Chemical Structure

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PI4KIIIβ PI4KIIIα PI4K PI4KII

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

PI4KIIIβ

0.026 μM (IC₅₀)

In Vitro

KR-27452 (Compound 2e) exhibits EC₅₀ of 0.236-0.813μM against RV-A and 0.104-0.664 μM against RV-B in H1HeLa cells, with CC₅₀ >100 μM and SI >123^[1].
KR-27452 has EC₅₀ of 0.118 μM against RV-C15 with SI >85 in HeLa-CDHR3 cells^[1].
KR-27452 shows EC₅₀ of 0.28-0.981μM against COX B1-B6 in H1HeLa cells, with CC₅₀ >100 μM and SI >102^[1].
KR-27452 (1-10 μM, 24 h) dose-dependently inhibits plaque formation in RV14-infected H1HeLa cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	Note	AUC	T_1/2	CL	T_max	F	V_{ss_obs}
Rat^[1]	5 mg/kg	i.v.	文献审核	1.8 μg·h/mL	6.41 h	2.82 L/h/kg	/	/	2.23 L/kg
Rat^[1]	10 mg/kg	p.o.	文献审核	1.44 μg·h/mL	4.2 h	1.62 μg/mL	0.42 h	52.4 %	/

Molecular Weight

453.55

Formula

C₂₄H₂₇N₃O₄S

SMILES

O=C(N(CCCO)C)C1=CC(C2=C(C)N=C(NC(CC3=CC=CC=C3)=O)S2)=CC=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ayele SA, et al. 2-amido-3-aryl-4-methyl-thiazole derivatives as broad-spectrum anti-rhinoviral agents. Eur J Med Chem. 2026;302(Pt 3):118318. [Content Brief]

KR-27452 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KR-27452KR27452KR 27452PI4KEnterovirusPhosphatidylinositol 4 kinasesPI4 kinasesRhinovirusHRVHRVsHEVHEVsRV-A,RV-B,RV-C15,HeLa,HeLa-CDHR3Inhibitorinhibitorinhibit

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