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Cat. No.: HY-117599

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JPC-3210

JPC-3210 is an orally active aminomethylphenol. JPC-3210 exhibits anti-malarial activity with a mean IC₅₀ ranging from 2.5 to 19 nM. JPC-3210 works by inhibiting the hemoglobin digestion pathway and promoting regulators of protein translation. JPC-3210 can inhibit CYP2D6 and CYP3A4 isozymes. JPC-3210 suppresses P. berghei infection in mice model. JPC-3210 possesses prophylactic protection in vivo. JPC-3210 can be studied in research on malaria prevention.

For research use only. We do not sell to patients.

CAS No.: 1609655-35-7

Formula: C₂₁H₂₆F₄N₂O

Molecular Weight:398.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

JPC-3210 Chemical Structure

CAS No.: 1609655-35-7

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Biological Activity

Description

JPC-3210 is an orally active aminomethylphenol. JPC-3210 exhibits anti-malarial activity with a mean IC₅₀ ranging from 2.5 to 19 nM. JPC-3210 works by inhibiting the hemoglobin digestion pathway and promoting regulators of protein translation. JPC-3210 can inhibit CYP2D6 and CYP3A4 isozymes. JPC-3210 suppresses P. berghei infection in mice model. JPC-3210 possesses prophylactic protection in vivo. JPC-3210 can be studied in research on malaria prevention^[1]^[2]^[3].

All Parasite Isoforms :

Amebae

Coccidia

Leishmania

Mite

Plasmodium

Toxoplasma

Trypanosoma

Schistosome

Chemical Information

CAS No. 1609655-35-7

Molecular Weight 398.44

Formula C₂₁H₂₆F₄N₂O

SMILES

OC1=C(C2=CC(F)=C(C(F)(F)F)N=C2)C=C(C(C)(C)C)C=C1CNC(C)(C)C

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

References

[1]. Birrell, G. W., et al., (2020). Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum. Molecular & cellular proteomics : MCP, 19(2), 308-325. [Content Brief]

[2]. Birrell, G. W., et al., (2018). Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention. Antimicrobial agents and chemotherapy, 62(4), e01335-17. [Content Brief]

[3]. Chavchich, M., et al., (2016). Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention. Antimicrobial agents and chemotherapy, 60(5), 3115-3118. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

JPC-3210 Related Classifications

HY-117599 Related Classifications

Anti-infection

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Keywords

JPC-3210
1609655-35-7
JPC3210
JPC 3210
Parasite
Inhibitor
inhibitor
inhibit

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