TPN729
TPN729 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 2.28 nM. TPN729 affects erectile function and it can be used for the research of erectile dysfunction.
For research use only. We do not sell to patients.
- CAS No.: 936951-20-1
- Formula: C25H36N6O4S
- Molecular Weight:516.66
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
PDE5 2.28 nM (IC50) |
PDE6 45.2 nM (IC50) |
PDE1 566 nM (IC50) |
PDE4 834 nM (IC50) |
PDE11 6090 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Sprague-Dawley rats with corpora cavernosa complete exposure[1]
-
Dosage:1.25, 2.5 and 5.0 mg/kg
-
Administration:Intraduodenal (i.d.) injection; 1.25, 2.5 and 5.0 mg/kg, once
-
Result:Dose-dependently increased the maximum intracavernous pressure (ICP) and ICP/blood pressure (BP).
Chemical Information
-
CAS No. 936951-20-1
-
Molecular Weight 516.66
-
Formula C25H36N6O4S
-
SMILES
O=S(C1=CC=C(OCCC)C(C(NC2=C3N(C)N=C2CCC)=NC3=O)=C1)(N(C)CCN4CCCC4)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz