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Cat. No.: HY-P11969

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10YX

10YX is a cyclic peptide probe targeting glypican-3 (GPC3) (K_d = 300.4 nM for human GPC3). It achieves tumor targeting by binding to GPC3 sitemap2 and serves as a PET imaging probe for tumor visualization and intrahepatic lesion localization. 10YX is useful for research on hepatocellular carcinoma.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₈₃H₁₂₄N₂₂O₂₅S₂
분자량:1894.14

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

맞춤형 펩타이드 합성

10YX Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

10YX (10 μM) binds to recombinant human GPC3 with a dissociation constant (K_d) of 300.4 nM^[1].
10YX binds to the predicted GPC3 binding site, and the highest-ranked docking conformation has a score of -6.664^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

10YX (200-300 μCi; i.v.) shows limited tumor uptake with a peak of 2.36% ID/mL at 10 min post-injection and a retention time of only 30 min in the HepG2 xenograft model^[1].
10YX (150-200 μCi; i.v.) exhibits a peak tumor uptake of 2.73% ID/g at 30 min and higher renal retention (45.41% ID/g at 4 h) in HepG2 tumor-bearing mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 1894.14
화학식 C₈₃H₁₂₄N₂₂O₂₅S₂
Sequence

AC-{Lys(PAMBA-DOTA)}-Cys-Leu-Asn-His-Glu-Leu-Phe-Gln-Thr-Cys-NH2 (Disulfide bridge: Cys2-Cys11)
Sequence Shortening

AC-{Lys(PAMBA-DOTA)}-CLNHELFQTC-NH2 (Disulfide bridge: Cys2-Cys11)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Animals and Diseases

Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers^[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Chen G, et al. 10P3Me: A GPC3-Targeted Peptide PET Probe for Subcutaneous and Orthotopic HCC Imaging. J Med Chem. 2025 Sep 25;68(18):19714-19725. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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