4-Chlorocinnamic acid
Based on 1 publication(s) in Google Scholar
4-Chlorocinnamic acid is a derivative of Cinnamic acid (HY-N0610A). 4-Chlorocinnamic acid inhibits the monophenolase and diphenolase activities of mushroom tyrosinase with IC50 values of 0.477 mM and 0.229 mM, respectively. 4-Chlorocinnamic acid inhibits the mycelial growth of Colletotrichum gloeosporioides. 4-Chlorocinnamic acid exhibits anticonvulsant activity against acute epilepsy induced by pentylenetetrazol.
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- Purity: 99.93%
- CAS No.: 1615-02-7
- 화학식: C9H7ClO2
- 분자량:182.61
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보관:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 4-Chlorocinnamic acid
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Biological Activity
IC50 values: 0.477 mM and 0.229 mM for monophenolase and diphenolase activities of mushroom tyrosinase, respectively
4-Chlorocinnamic acid inhibits both monophenolase and diphenolase activities of mushroom tyrosinase, with IC50 values of 0.477 mM and 0.229 mM, respectively[1].
4-Chlorocinnamic acid (0.5 mg/mL) inhibits the mycelial growth of Colletotrichum gloeosporioides in vitro with an inhibition rate of approximately 65%[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MRC-5 fibroblasts
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Concentration:3.12 μg/mL, 6.25 μg/mL, 12.5 μg/mL, 25 μg/mL, 50 μg/mL, 100 μg/mL
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Incubation Time:72 h
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Result:Did not significantly reduce the viability of MRC-5 fibroblasts at concentrations lower than 100 μg/mL.
Showed an IC50 value of >100 μg/mL.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice (both genders, weight 25-30 g) with PTZ-induced acute seizures[4]
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Dosage:100 mg/kg, 200 mg/kg, 300 mg/kg
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Administration:intraperitoneal injection
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Result:Prolonged the latent time of PTZ-induced seizures to 214.0 s, reduced the tonic seizure rate to 25% and the mortality rate to 50% (at the dose of 300 mg/kg).
Chemical Information
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CAS No. 1615-02-7
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Appearance Solid
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분자량 182.61
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화학식 C9H7ClO2
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Color White to off-white
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SMILES
O=C(O)/C=C/C1=CC=C(Cl)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
용액&용해도
DMSO : 100 mg/mL (547.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Cui Y, et al. Inhibition kinetics and molecular simulation of p-substituted cinnamic acid derivatives on tyrosinase. Int J Biol Macromol. 2017 Feb;95:1289-1297. [Content Brief]
[2]. Silva RHN, et al. Antimicrobial Activity of 4-Chlorocinnamic Acid Derivatives. Biomed Res Int. 2019 Apr 23;2019:3941242. [Content Brief]
[4]. Cuan Y, et al. Anticonvulsant Activity of Halogen-Substituted Cinnamic Acid Derivatives and Their Effects on Glycosylation of PTZ-Induced Chronic Epilepsy in Mice. Molecules. 2017 Dec 29;23(1):76. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.4762 mL | 27.3808 mL | 54.7615 mL | 136.9038 mL |
| 5 mM | 1.0952 mL | 5.4762 mL | 10.9523 mL | 27.3808 mL | |
| 10 mM | 0.5476 mL | 2.7381 mL | 5.4762 mL | 13.6904 mL | |
| 15 mM | 0.3651 mL | 1.8254 mL | 3.6508 mL | 9.1269 mL | |
| 20 mM | 0.2738 mL | 1.3690 mL | 2.7381 mL | 6.8452 mL | |
| 25 mM | 0.2190 mL | 1.0952 mL | 2.1905 mL | 5.4762 mL | |
| 30 mM | 0.1825 mL | 0.9127 mL | 1.8254 mL | 4.5635 mL | |
| 40 mM | 0.1369 mL | 0.6845 mL | 1.3690 mL | 3.4226 mL | |
| 50 mM | 0.1095 mL | 0.5476 mL | 1.0952 mL | 2.7381 mL | |
| 60 mM | 0.0913 mL | 0.4563 mL | 0.9127 mL | 2.2817 mL | |
| 80 mM | 0.0685 mL | 0.3423 mL | 0.6845 mL | 1.7113 mL | |
| 100 mM | 0.0548 mL | 0.2738 mL | 0.5476 mL | 1.3690 mL |
4-Chlorocinnamic acid Related Classifications
HY-Y0729 Related Classifications
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