S1P1 agonist 1
Based on 1 Customer Validation
S1P1 Agonist 1 is a S1P1 agonist with immunomodulatory activities.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.92%
- CAS No.: 1220973-37-4
- 화학식: C22H22ClN3O5
- 분자량:443.88
-
보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- Protocol
- 순도&문서
- References
-
Help & FAQs
-
HY-12288
Ozanimod
-
HY-18166
NIBR0213
-
HY-104069R
S1P1 agonist 1 (Standard)
-
HY-19511
GSK2018682
-
HY-123963
C-178
-
HY-W555382
Pseudane IX
-
HY-116392B
DL-threo-PDMP hydrochloride
-
HY-162465
BDW568
-
HY-116392F
D-threo-PDMP hydrochloride
-
HY-12288R
Ozanimod (Standard)
-
HY-W587524
Carboxyphosphamide
-
HY-114619
Oleyl anilide
Biological Activity
S1P1[1]
S1P1 Agonist 1 binds to S1P1 is internalized and activates intracellular AKT and ERKs cellular signaling pathways. S1P1 Agonist 1 mediated S1P1 downregulation is independent of sphingosine kinase activity indicating it to be a direct agonist of S1P1. S1P1 Agonist 1 decreases cell surface expression of S1P1 in in vitro cell culture model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1220973-37-4
-
Appearance Solid
-
분자량 443.88
-
화학식 C22H22ClN3O5
-
Color White to off-white
-
SMILES
OCC(C1=CC2=CC(C3=NOC(C4=CC=C(OCCC)C(Cl)=C4)=N3)=CC=C2O1)(N)CO
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : ≥ 125 mg/mL (281.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
Rats: EAE is induced in female Lewis rats with guinea pig MBP (25 μg/rat). EAE developed rats are divided into 3 groups on day 11 or 12 after immunization and administered vehicle or S1P1 Agonist 1 (3 or 1.3 mg/kg) or FTY720 (1 mg/kg) orally every day until day 26. Rats are administrated orally with 1.3 mg/kg S1P1 Agonist 1, 1 mg/kg FTY720 and vehicle. After post administration, heart rates are measured at 1, 2, 4, 6, 12, and 24 hr[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
순도&문서
-
Data Sheet (272 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2529 mL | 11.2643 mL | 22.5286 mL | 56.3215 mL |
| 5 mM | 0.4506 mL | 2.2529 mL | 4.5057 mL | 11.2643 mL | |
| 10 mM | 0.2253 mL | 1.1264 mL | 2.2529 mL | 5.6322 mL | |
| 15 mM | 0.1502 mL | 0.7510 mL | 1.5019 mL | 3.7548 mL | |
| 20 mM | 0.1126 mL | 0.5632 mL | 1.1264 mL | 2.8161 mL | |
| 25 mM | 0.0901 mL | 0.4506 mL | 0.9011 mL | 2.2529 mL | |
| 30 mM | 0.0751 mL | 0.3755 mL | 0.7510 mL | 1.8774 mL | |
| 40 mM | 0.0563 mL | 0.2816 mL | 0.5632 mL | 1.4080 mL | |
| 50 mM | 0.0451 mL | 0.2253 mL | 0.4506 mL | 1.1264 mL | |
| 60 mM | 0.0375 mL | 0.1877 mL | 0.3755 mL | 0.9387 mL | |
| 80 mM | 0.0282 mL | 0.1408 mL | 0.2816 mL | 0.7040 mL | |
| 100 mM | 0.0225 mL | 0.1126 mL | 0.2253 mL | 0.5632 mL |
S1P1 agonist 1 Related Classifications
HY-104069 Related Classifications
Powered by Bioz