Deltorphin I
Based on 1 Customer Validation
Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity.
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- Purity: 96.69%
- CAS No.: 122752-15-2
- 화학식: C37H52N8O10
- 분자량:768.86
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
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All Opioid Receptor Isoforms
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Biological Activity
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δ Opioid Receptor/DOR |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
<0.01 nM
Compound: Deltorphin-2
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Activity at delta opioid receptor assessed as increase in calcium level in CHO cells by aequorin luminescence based calcium assay
Activity at delta opioid receptor assessed as increase in calcium level in CHO cells by aequorin luminescence based calcium assay
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[PMID: 17266203] |
| CHO | EC50 |
<0.01 nM
Compound: deltorphin-II
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Antagonist activity at delta opioid receptor expressed in CHO cells assessed as release of intracellular calcium ions by aequorin luminescence-based calcium assay
Antagonist activity at delta opioid receptor expressed in CHO cells assessed as release of intracellular calcium ions by aequorin luminescence-based calcium assay
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[PMID: 18207400] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 122752-15-2
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Appearance Solid
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분자량 768.86
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화학식 C37H52N8O10
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Color White to off-white
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Synonyms
Deltorphin 1; Deltorphin C; [D-Ala2] Deltorphin I
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Sequence
Tyr-{d-Ala}-Phe-Asp-Val-Val-Gly-NH2
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Sequence Shortening
Y-{d-Ala}-FDVVG-NH2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 25 mg/mL (32.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
Mice[1]
Male Kunming mice (20.0±1.0 g) are used. In order to investigate the chronic effect of Melatonin on opioid receptor agonist analgesia, 18, 17, 16 and 21 mice are treated with Melatonin (0, 0.5, 1 and 2.5 mg/kg, respectively) twice daily for 4 days. On the 5th day, 8, 8, 8 and 9 mice are administered with Endomorphin-1 18 μg/mouse (corresponding to 0, 0.5, 1 and 2.5 mg/kg Melatonin, respectively), while 10, 9, 8 and 12 mice are administered with Deltorphin I 20 μg/mouse (corresponding to 0, 0.5, 1 and 2.5 mg/kg Melatonin, respectively). Subsequently tail-flick latency is measured at 10 min interval within 60 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
순도&문서
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3006 mL | 6.5031 mL | 13.0063 mL | 32.5157 mL |
| 5 mM | 0.2601 mL | 1.3006 mL | 2.6013 mL | 6.5031 mL | |
| 10 mM | 0.1301 mL | 0.6503 mL | 1.3006 mL | 3.2516 mL | |
| 15 mM | 0.0867 mL | 0.4335 mL | 0.8671 mL | 2.1677 mL | |
| 20 mM | 0.0650 mL | 0.3252 mL | 0.6503 mL | 1.6258 mL | |
| 25 mM | 0.0520 mL | 0.2601 mL | 0.5203 mL | 1.3006 mL | |
| 30 mM | 0.0434 mL | 0.2168 mL | 0.4335 mL | 1.0839 mL |
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