(S,R,S)-AHPC-C4-NH2 hydrochloride
Based on 1 Customer Validation
(S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC.
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- Purity: 99.69%
- CAS No.: 2245697-83-8
- 화학식: C27H40ClN5O4S
- 분자량:566.16
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
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VHL |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2245697-83-8
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Appearance Solid
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분자량 566.16
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화학식 C27H40ClN5O4S
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Color Light yellow to green yellow
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SMILES
O=C(N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)=O)CCCCN.[H]Cl
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Synonyms
VH032-C4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 28
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : ≥ 109.6 mg/mL (193.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 50 mg/mL (88.31 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.7663 mL | 8.8314 mL | 17.6629 mL | 44.1571 mL |
| 5 mM | 0.3533 mL | 1.7663 mL | 3.5326 mL | 8.8314 mL | |
| 10 mM | 0.1766 mL | 0.8831 mL | 1.7663 mL | 4.4157 mL | |
| 15 mM | 0.1178 mL | 0.5888 mL | 1.1775 mL | 2.9438 mL | |
| 20 mM | 0.0883 mL | 0.4416 mL | 0.8831 mL | 2.2079 mL | |
| 25 mM | 0.0707 mL | 0.3533 mL | 0.7065 mL | 1.7663 mL | |
| 30 mM | 0.0589 mL | 0.2944 mL | 0.5888 mL | 1.4719 mL | |
| 40 mM | 0.0442 mL | 0.2208 mL | 0.4416 mL | 1.1039 mL | |
| 50 mM | 0.0353 mL | 0.1766 mL | 0.3533 mL | 0.8831 mL | |
| 60 mM | 0.0294 mL | 0.1472 mL | 0.2944 mL | 0.7360 mL | |
| 80 mM | 0.0221 mL | 0.1104 mL | 0.2208 mL | 0.5520 mL | |
| DMSO | 100 mM | 0.0177 mL | 0.0883 mL | 0.1766 mL | 0.4416 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(S,R,S)-AHPC-C4-NH2 hydrochloride Related Classifications
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