S-MTC

S-MTC (10 or 100 μM) reduces cellular NO release in the absence of Aβ_1-42. At 100 μM, S-MTC decreases cell viability. S-MTC (100 μM) significantly lowers nitrite production (11.2±1.1 μM) when compared to control (no NOS inhibitor exposure; 19.6±1.2 μM). Nitrite productions after Aβ_1-42 and L-NOARG (100 μM) or Aβ_1-42 and S-MTC (100 μM) treatments are significantly lower than Aβ_1-42 alone (33.5±2.0 and 34.5±1.6 μM, respectively). S-MTC (100 μM) is able to significantly reduce nitrite production (25.2±1.1 μM) as compared to Aβ_1-42 treatment alone (38.3±2.7 μM), when administered after Aβ_1-42 at the 1 h time point. S-MTC (100 μM) concentration decreases both MTT (87±1% of control) and NR (80±1% of control, respectively) levels. The co-administration of S-MTC (100 μM) and Aβ_1-42 significantly reverses the effects of Aβ_1-42 alone (72±2% vs 61±2% of control)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.