country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-184590

Copy Link Print Information

AB12-82

AB12-82 is a selective dopamine receptor agonist with a K_i value of 1.88 nM for human D₃R. AB12-82 achieves subtype-selective D₃R activation by enhancing interactions with the D₃R H291·32 residue. AB12-82 can be used in the research of nervous system-related diseases.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₆H₃₃N₅O₃
분자량:463.57

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AB12-82 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Human D₃ Receptor

1.88 nM (Ki)

Human D₂ Receptor

41 nM (Ki)

All Dopamine Receptor Isoforms :

In Vitro

AB12-82 (compound 6d) binds to hD₃R with a K_i value of 1.88 nM, and exhibits a 21.8-fold binding selectivity over hD₂L R (it binds to hD₂R with a K_i value of 41 nM)^[1].
AB12-82 acts as a partial agonist of hD₃R, with a pEC₅₀ of 11.76 (0.00174 nM) and an efficacy of 84.57%. Its potency for hD₃R is >575000-fold more selective than that for hD₂R^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 463.57
화학식 C₂₆H₃₃N₅O₃
SMILES

NC1=CC=C(C=N1)[C@H]2CN([C@H](CO2)C)CC3C(CCNC(C4=CC5=C(N4)C=CC(OC)=C5)=O)C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Arroyo-Urea S, et al. A Ligand-Triggered Receptor Conformation Enables the Design of Selective Agonists for the Dopamine 3 Receptor (D₃R) Using a Bitopic Strategy. JACS Au. 2026.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

AB12-82

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AB12-82 Related Classifications

HY-184590 Related Classifications