AG 370
Based on 1 Customer Validation
AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor.
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- Purity: 97.0%
- CAS No.: 134036-53-6
- 화학식: C15H9N5
- 분자량:259.27
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보관:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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PDGFR 20 μM (IC50) |
AG 370 blocks mitogenesis induced by epidermal growth factor (IC50 of 50 μM) and human serum (IC50 of 50 μM)[1][1].
In Digitonin-permeabilized fibroblasts as well as in intact fibroblasts, tyrphostin AG 370 inhibits PDGF receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates (pp120, pp85, and pp75) which coprecipitate with the PDGF receptor[1][1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 134036-53-6
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Appearance Solid
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분자량 259.27
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화학식 C15H9N5
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Color White to yellow
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SMILES
N#C/C(C#N)=C(N)/C(C#N)=C\C1=CC=C(NC=C2)C2=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
DMSO : 30 mg/mL (115.71 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8570 mL | 19.2849 mL | 38.5698 mL | 96.4246 mL |
| 5 mM | 0.7714 mL | 3.8570 mL | 7.7140 mL | 19.2849 mL | |
| 10 mM | 0.3857 mL | 1.9285 mL | 3.8570 mL | 9.6425 mL | |
| 15 mM | 0.2571 mL | 1.2857 mL | 2.5713 mL | 6.4283 mL | |
| 20 mM | 0.1928 mL | 0.9642 mL | 1.9285 mL | 4.8212 mL | |
| 25 mM | 0.1543 mL | 0.7714 mL | 1.5428 mL | 3.8570 mL | |
| 30 mM | 0.1286 mL | 0.6428 mL | 1.2857 mL | 3.2142 mL | |
| 40 mM | 0.0964 mL | 0.4821 mL | 0.9642 mL | 2.4106 mL | |
| 50 mM | 0.0771 mL | 0.3857 mL | 0.7714 mL | 1.9285 mL | |
| 60 mM | 0.0643 mL | 0.3214 mL | 0.6428 mL | 1.6071 mL | |
| 80 mM | 0.0482 mL | 0.2411 mL | 0.4821 mL | 1.2053 mL | |
| 100 mM | 0.0386 mL | 0.1928 mL | 0.3857 mL | 0.9642 mL |
AG 370 Related Classifications
HY-116111 Related Classifications
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