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Cat. No.: HY-181584

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AKI-062a

AKI-062a is a non-selective kinase inhibitor, such as a CK1γ inhibitor. AKI-062a binds to and inhibits WNT pathway kinases and GSK3β. At a concentration of 1 μM, AKI-062a binds to 17 kinases, with a binding activity of <10% of that of the control group.

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CAS No.: 1093303-07-1
화학식: C₂₀H₂₁N₇O
분자량:375.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

AKI-062a Chemical Structure

CAS No.: 1093303-07-1

사이즈

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

GSK-3β

All GSK-3 Isoforms :

In Vitro

AKI-062a (1 μM) demonstrates non-selective kinase binding, interacting with 17 kinases including the WNT pathway kinase GSK3β^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1093303-07-1
분자량 375.43
화학식 C₂₀H₂₁N₇O
SMILES

CN(C)CC(NC1=NNC(C1=C2)=CC=C2C(N=N3)=CN3CC4=CC=CC=C4)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Capener JL, et al. Development of a Chemical Probe to Enable Characterization of the Casein Kinase 1γ Subfamily. J Med Chem. 2026 Feb 12;69(3):2666-2684. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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AKI-062a

All GSK-3 Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AKI-062a Related Classifications

HY-181584 Related Classifications