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Cat. No.: HY-12585

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AM-4668

AM-4668 is a GPR40 agonist for type 2 diabetes. EC₅₀s of 3.6 nM and 36 nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.0%
CAS No.: 1011531-27-3
화학식: C₂₄H₁₉F₃N₂O₄S
분자량:488.48

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

AM-4668 Chemical Structure

CAS No.: 1011531-27-3

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

AM-4668 is a GPR40 agonist for type 2 diabetes. EC₅₀s of 3.6 nM and 36 nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively^[1].

IC₅₀ & Target

EC50: 3.6 nM (GPR40, in A9 cells), 36 nM (GPR40, in CHO cells)^[1]

All Free Fatty Acid Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A9	EC₅₀	3.6 nM Compound: 10, AM-4668	Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay	[PMID: 24900872]
CHO	EC₅₀	36 nM Compound: 10, AM-4668	Agonist activity at human GPR40 expressed in CHO cells by aequorin assay Agonist activity at human GPR40 expressed in CHO cells by aequorin assay	[PMID: 24900872]

Chemical Information

CAS No. 1011531-27-3
Appearance Solid
분자량 488.48
화학식 C₂₄H₁₉F₃N₂O₄S
Color White to off-white
SMILES

OC(C[C@H](C1=NOC=C1)C(C=C2)=CC=C2OCC(S3)=C(C)N=C3C4=CC=C(C(F)(F)F)C=C4)=O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu JJ, et al. Optimization of GPR40 Agonists for Type 2 Diabetes. ACS Med Chem Lett. 2014 Feb 6;5(5):517-21. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

AM-4668

Fasiglifam

DC260126

AMG 837 calcium hydrate

TUG-770

GPR40 Activator 2

AMG 837

GPR40 Activator 1

GW-1100

Fasiglifam (Standard)

DC260126 (Standard)

AMG 837 sodium salt

AP5

All Free Fatty Acid Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

AM-4668

Fasiglifam

DC260126

AMG 837 calcium hydrate

TUG-770

GPR40 Activator 2

AMG 837

GPR40 Activator 1

GW-1100

Fasiglifam (Standard)

DC260126 (Standard)

AMG 837 sodium salt

AP5

All Free Fatty Acid Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AM-4668 Related Classifications

HY-12585 Related Classifications

Bioz