Antcin A
Based on 1 Customer Validation
Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease.
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- Purity: 99.71%
- CAS No.: 163597-24-8
- 화학식: C29H42O4
- 분자량:454.64
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보관:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
NLRP3[1].
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
39.4 μM
Compound: 17
|
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
|
[PMID: 24387703] |
| BV-2 | IC50 |
4.1 μM
Compound: 15
|
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS-dependent nitrite production after 24 hrs by Griess method
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS-dependent nitrite production after 24 hrs by Griess method
|
[PMID: 21028898] |
| BV-2 | IC50 |
45.9 μM
Compound: 15
|
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of NOX-dependent ROS production up to 50 uM
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of NOX-dependent ROS production up to 50 uM
|
[PMID: 21028898] |
| Daoy | ED50 |
13.2 μg/mL
Compound: 30
|
Cytotoxicity against human DaOY cells after 3 days by MTT assay
Cytotoxicity against human DaOY cells after 3 days by MTT assay
|
[PMID: 21115251] |
| HeLa | ED50 |
>20 μg/mL
Compound: 30
|
Cytotoxicity against human HeLa cells after 3 days by MTT assay
Cytotoxicity against human HeLa cells after 3 days by MTT assay
|
[PMID: 21115251] |
| HEp-2 | ED50 |
>20 μg/mL
Compound: 30
|
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
|
[PMID: 21115251] |
| KB | EC50 |
4.9 μM
Compound: 15
|
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
|
[PMID: 21028898] |
| MCF7 | ED50 |
13.3 μg/mL
Compound: 30
|
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
|
[PMID: 21115251] |
| MDA-MB-231 | IC50 |
29.6 μM
Compound: 17
|
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
|
[PMID: 24387703] |
Chemical Information
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CAS No. 163597-24-8
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Appearance Solid
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분자량 454.64
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화학식 C29H42O4
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Color Off-white to light yellow
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SMILES
C[C@@]12C3=C(CC[C@@]1([H])[C@@H](C(CC2)=O)C)[C@@]4([H])[C@](CC3=O)([C@@](CC4)([H])[C@H](C)CCC(C(C)C(O)=O)=C)C
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Structure Classification
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Initial Source
Antrodia cinnamomea
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
순도&문서
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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