country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-183291

Copy Link Print Information

Antibacterial agent 343

Antibacterial agent 343 (Compound 47) is an Antibacterial agent. Antibacterial agent 343 binds to the allosteric site of PBP2a to open its active site. Antibacterial agent 343 disrupts bacterial cell membranes, leading to protein leakage. Antibacterial agent 343 interacts with DNA and inhibits replication and transcription. Antibacterial agent 343 induces ROS accumulation. Antibacterial agent 343 exhibits antibacterial activity against MRSA, Staphylococcus aureus, and Enterococcus faecalis. Antibacterial agent 343 can be used for the research of methicillin-resistant Staphylococcus aureus infections.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₃₃H₃₄N₈O₉S₂
분자량:750.80

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 343 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All DNA/RNA Synthesis Isoforms :

In Vitro

Antibacterial agent 343 exhibits antibacterial activity and potently inhibits MRSA, with an MIC₅₀ of 0.5 μg/mL^[1].
Antibacterial agent 343 (5-40 μg/mL; 24 h) exhibits low cytotoxicity against normal LO2 and BEAS-2B cells, with no significant reduction in cell viability observed even at concentrations up to 40 μg/mL after 24 h of treatment^[1].
Antibacterial agent 343 (0.25-1 μg/mL; 0-14 h) inhibits the growth of MRSA in a concentration-dependent manner^[1].
Antibacterial agent 343 (0.5-4 μg/mL) promotes concentration-dependent reactive oxygen species (ROS) accumulation in MRSA, and the ROS level increases to 2.5 times that of the control group at 1× MIC, thereby inducing oxidative stress^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

LO2 normal human liver cells, BEAS-2B normal human bronchial epithelial cells
Concentration:

5-40 μg/mL
Incubation Time:

24 h
Result:

Did not cause any significant reduction in cell viability in either LO2 or BEAS-2B cell lines at all tested concentrations.

Chemical Information

분자량 750.80
화학식 C₃₃H₃₄N₈O₉S₂
SMILES

NC1=NC(/C(C(NC2C(N3C2SCC(CN4CCN(C5=CC=C6C7=C5C=CC=C7C(N(C(CO)CO)C6=O)=O)CC4)=C3C(O)=O)=O)=O)=N/OC)=CS1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Wang JX, et al. Novel naphthalimide-derived cephalosporins as potential multitargeting anti-MRSA candidates. Bioorg Chem. Published online April 19, 2026. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Antibacterial agent 343

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Antibacterial agent 343 Related Classifications

HY-183291 Related Classifications