AP2238
AP2238 is a dual-function acetylcholinesterase (AChE) inhibitor with Ki values for human AChE (HuAChE) and butyrylcholinesterase (BuChE) of 21.7 and 48.9 μM respectively. AP2238 blocks the pro-fibrotic interaction between the peripheral site of AChE and Aβ, and can inhibit Aβ aggregation. AP2238 can be used for the research of Alzheimer's disease.
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- CAS No.: 553681-56-4
- 화학식: C26H25NO4
- 분자량:415.48
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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hAChE 21.7 μM (Ki) |
hBCHE 48.9 μM (Ki) |
Chemical Information
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CAS No. 553681-56-4
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분자량 415.48
-
화학식 C26H25NO4
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SMILES
O=C1C(C2=CC=C(CN(C)CC3=CC=CC=C3)C=C2)=CC4=CC(OC)=C(OC)C=C4O1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Piazzi L, et al. 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy. J Med Chem. 2003 Jun 5;46(12):2279-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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