ARN25062
ARN25062 (compound 27) is a CDC42/RHOJ inhibitor with antitumor activity. ARN25062 is a novel trisubstituted pyrimidine derivative.
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- CAS No.: 3036492-85-7
- 화학식: C22H21F3N4
- 분자량:398.42
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
5.1 μM
Compound: 27; ARN25062
|
Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
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[PMID: 37026468] |
| A-375 | IC50 |
5.1 μM
Compound: ARN25062
|
Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
Antiproliferative activity against human A-375 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
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[PMID: 38866385] |
| SK-MEL-28 | IC50 |
6.1 μM
Compound: 27; ARN25062
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Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
|
[PMID: 37026468] |
| SK-MEL-28 | IC50 |
6.1 μM
Compound: ARN25062
|
Antiproliferative activity against human SK-MEL-28 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
Antiproliferative activity against human SK-MEL-28 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
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[PMID: 38866385] |
| SK-MEL3 | IC50 |
4.6 μM
Compound: 27; ARN25062
|
Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
|
[PMID: 37026468] |
| SK-MEL3 | IC50 |
4.6 μM
Compound: ARN25062
|
Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
Antiproliferative activity against human SK-MEL3 cells harboring BRAF V600E mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
|
[PMID: 38866385] |
| SW480 | IC50 |
5.9 μM
Compound: 27; ARN25062
|
Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant assessed as reduction in cell viability incubated for overnight by CellTiter-Glo assay
|
[PMID: 37026468] |
| SW480 | IC50 |
5.9 μM
Compound: ARN25062
|
Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
Antiproliferative activity against human SW480 cells harboring KRAS G12V mutant and activity RHOJ/CDC42 assessed as inhibition of cell growth incubated for overnight by CellTiterGlo assay
|
[PMID: 38866385] |
Chemical Information
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CAS No. 3036492-85-7
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분자량 398.42
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화학식 C22H21F3N4
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SMILES
FC(F)(C1=CC(NC2=CC(C3=CC=CC=C3)=NC(C4CCNCC4)=N2)=CC=C1)F
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ARN25062 Related Classifications
HY-167828 Related Classifications
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