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Cat. No.: HY-147391

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ASIC-IN-1

ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC₅₀ value of < 10 µM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 308088-10-0
화학식: C₂₃H₂₅N₃O₂
분자량:375.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

ASIC-IN-1 Chemical Structure

CAS No.: 308088-10-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC₅₀ value of < 10 µM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity^[1].

IC₅₀ & Target

IC₅₀: < 10 µM (acid sensing ion channel)^[1]

All Sodium Channel Isoforms :

In Vivo

ASIC-IN-1 (compound A) (50 mg/kg; i.p.) causes a dose- dependent reduction of the pain intensity as evaluated by the flinching behavior on formalin-induced spontaneous pain evoked by intraplantar injection of formalin in the rat^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

150-180 g male Sprague-Dawley rats^[1]
Dosage:

50 mg/kg
Administration:

I.p.
Result:

Blocked acute tonic pain induced by formalin injection in the paw.

Related Protocols :

Two-electrode voltage clamp in Xenopus oocytes

Chemical Information

CAS No. 308088-10-0
분자량 375.46
화학식 C₂₃H₂₅N₃O₂
SMILES

CC1=NC2=CC=CC=C2C(N3CCN(CC(C4=CC=C(OC)C=C4)=O)CC3)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rahul Vohra, et al. Compositions and methods for modulating gated ion channels. WO2007071055A1.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

ASIC-IN-1

All Sodium Channel Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vivo

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ASIC-IN-1 Related Classifications

HY-147391 Related Classifications

Bioz

Keywords

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