AZ99
AZ99 (compound 7) is a potent ABCG2 inhibitor. AZ99 inhibits ABCG2-mediated transport of estrone-3-sulfate (E1S) into proteoliposomes and ABCG2 ATPase activity.
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- 화학식: C30H35N3O3
- 분자량:485.62
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Chemical Information
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분자량 485.62
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화학식 C30H35N3O3
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SMILES
O=C1N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CC(C)C)C4=C(C5=CC=C(OC6CCCC6)C=C5N4)C[C@H]31)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
용액&용해도
In Vitro:
DMSO : 100 mg/mL (205.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (10.30 mM); Suspended solution
This protocol yields a suspended solution of ≥ 5 mg/mL (saturation unknown). Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0592 mL | 10.2961 mL | 20.5922 mL | 51.4806 mL |
| 5 mM | 0.4118 mL | 2.0592 mL | 4.1184 mL | 10.2961 mL | |
| 10 mM | 0.2059 mL | 1.0296 mL | 2.0592 mL | 5.1481 mL | |
| 15 mM | 0.1373 mL | 0.6864 mL | 1.3728 mL | 3.4320 mL | |
| 20 mM | 0.1030 mL | 0.5148 mL | 1.0296 mL | 2.5740 mL | |
| 25 mM | 0.0824 mL | 0.4118 mL | 0.8237 mL | 2.0592 mL | |
| 30 mM | 0.0686 mL | 0.3432 mL | 0.6864 mL | 1.7160 mL | |
| 40 mM | 0.0515 mL | 0.2574 mL | 0.5148 mL | 1.2870 mL | |
| 50 mM | 0.0412 mL | 0.2059 mL | 0.4118 mL | 1.0296 mL | |
| 60 mM | 0.0343 mL | 0.1716 mL | 0.3432 mL | 0.8580 mL | |
| 80 mM | 0.0257 mL | 0.1287 mL | 0.2574 mL | 0.6435 mL | |
| 100 mM | 0.0206 mL | 0.1030 mL | 0.2059 mL | 0.5148 mL |
AZ99 Related Classifications
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