BChE-IN-14
BChE-IN-14 (compound 19c) is a selective butyrylcholinesterase (BChE) inhibitor with IC50s of 0.23 and 0.011 μM for eqBChE and hBChE, respectively. BChE-IN-14 shows good blood brain barrier permeation and primary cell safety. BChE-IN-14 is able to restore cognitive impairment in vivo, it can be used for the research of Alzheimer’s disease.
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- CAS No.: 2700896-78-0
- 화학식: C24H29N
- 분자량:331.49
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
IC50: 0.23 μM (eqBChE), 0.011 μM (hBChE)[1]
BChE-IN-14 (0.0001-100 μM) inhibits eqBChE from house serum and hBChE with IC50s of 0.23 and 0.011 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice with oligomerized Aβ1-42 peptide injection[1]
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Dosage:15 mg/kg
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Administration:Oral gavage; 15 mg/kg for Aβ1-42 injection days 3-8
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Result:Improved memory and cognitive function in vivo and showed a shorter latency than donepezil.
Chemical Information
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CAS No. 2700896-78-0
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분자량 331.49
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화학식 C24H29N
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SMILES
CCCCN(CC1=CC=C2C=CC=CC2=C1)CCCC3=CC=CC=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BChE-IN-14 Related Classifications
HY-151389 Related Classifications
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