Rondaptivon pegol sodium
Based on 1 Customer Validation
Rondaptivon pegol (BT200) sodium is a pegylated aptamer targeting von Willebrand factor (VWF), with an EC50 of 33 nM in humans. Rondaptivon pegol sodium effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol sodium inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol sodium can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 93.15%
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
Rondaptivon pegol sodium (3 μg/mL; 60 min) reduces VWF activity in citrated human plasma to 28.5% of the normal level[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Rondaptivon pegol sodium (0.1-5.0 mg/kg; intravenous injection; single administration) attenuates acute myocardial ischemia-reperfusion injury in mice by targeting VWF[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 6-8 weeks old, wild-type, myocardial ischemia-reperfusion injury model)[2]
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Dosage:0.1 mg/kg; 0.5 mg/kg; 5.0 mg/kg
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Administration:i.v.; single dose at reperfusion start
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Result:Accumulated in ischemic myocardium, inhibited VWF A1 activity, prolonged bleeding time, reduced microvascular obstruction, alleviated inflammatory response and cardiomyocyte apoptosis, significantly decreased infarct size, and improved left ventricular ejection fraction and fractional shortening.
Chemical Information
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Appearance Solid
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Color Off-white to light yellow
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SMILES
[Rondaptivon pegol sodium]
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Synonyms
BT200 sodium
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
순도&문서
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (1518 KB)
References
[1]. Zhu S, et al. Potent and rapid reversal of the von Willebrand factor inhibitor aptamer BT200. J Thromb Haemost. 2020 Jul;18(7):1695-1704. [Content Brief]
[2]. Chen X, et al. Aptamer BT200 is protective against myocardial ischemia-reperfusion injury in mice. J Thromb Haemost. 2025;23(1):222-234. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rondaptivon pegol sodium Related Classifications
HY-153999A Related Classifications
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