C3361
C3361 is a moderate specific Plasmodium falciparum hexose transporter 1 (PfHT1) and Plasmodium berghei hexose transporter 1 (PbHT1) inhibitor with Ki values of 8.6 and 9.4 μM. C3361 inhibits TgGT1 with a Ki of 82 μM. C3361 attenuates hepatic (IC50 = 15 μM) and ookinete development of P. berghei. C3361 can suppress the growth of blood-stage parasites. C3361 can be used for the research of infection, such as malaria.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 91042-00-1
- 화학식: C17H32O6
- 분자량:332.43
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All Parasite Isoforms
More
Biological Activity
제품 설명
In Vitro
C3361 reduces 75% ookinete formation[1].
C3361 (1-100 μM, 68 h) prevent the maturation of the liver-stage schizonts in sporozoite-infected hepatoma cells[1].
C3361 shows growth inhibition of P. berghei with an IC50 of 15 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Sporozoite-infected hepatoma cells
-
Concentration:1, 10, 50 and 100 μM
-
Incubation Time:68 h
-
Result:Decreased area of the liver schizonts.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:GFP-expressing parasite-infected blood cells infected mice models[1]
-
Dosage:2 mg/kg
-
Administration:Intraperitoneally injection, daily
-
Result:Reduced 45% parasitemia from days 3-5.
Chemical Information
-
CAS No. 91042-00-1
-
분자량 332.43
-
화학식 C17H32O6
-
SMILES
C=CCCCCCCCCCO[C@H]1[C@@H]([C@H](OC([C@@H]1O)O)CO)O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Huang J, et al. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2017749118. [Content Brief]
[2]. Blume M, et al. A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs. FASEB J. 2011 Apr;25(4):1218-29. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
C3361 Related Classifications
HY-17656 Related Classifications
Powered by Bioz