CL-13
CL-13 is a butyrylcholinesterase (BChE) inhibitor, with an IC50 of 1.15 μM, and a selectivity index (SI) of 9.2 for acetylcholinesterase. CL-13 shows antioxidant activity in SH-SY5Y cells (DPPH EC50 = 47.01 μM) and has the ability to chelate metals involved in Aβ aggregation and/or oxidative stress, showing no neurotoxicity at 50 μM. CL-13 can reverse cognitive impairment caused by scopolamine (HY-N0296) without affecting the mice's motor skills.
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- 화학식: C29H32N4OS
- 분자량:484.66
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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BChE 1.15 μM (IC50) |
Chemical Information
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분자량 484.66
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화학식 C29H32N4OS
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SMILES
S=C(N/N=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)NC2=C(C=CC=C3)C3=NC4=CC=CC=C42
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Gleyton Leonel Silva Sousa, et al. Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies. Eur J Med Chem. 2025 Jan 5:281:117030. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CL-13 Related Classifications
HY-168301 Related Classifications
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