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Cat. No.: HY-116436

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Clathrodin

Clathrodin is a voltage-gated sodium channel modulator that modulates channel activity and reduces inward sodium current. Clathrodin can be used in research related to neurological diseases.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 135383-64-1
화학식: C₁₁H₁₃N₅O
분자량:231.25

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Clathrodin Chemical Structure

CAS No.: 135383-64-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Clathrodin is a voltage-gated sodium channel modulator that modulates channel activity and reduces inward sodium current. Clathrodin can be used in research related to neurological diseases^[1]^[2]^[3]^[4]^[5].

All Sodium Channel Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	ED₅₀	1.33 μg/mL Compound: 1	Cytotoxicity against CHOK1 cells Cytotoxicity against CHOK1 cells	10.1021/np50074a051

In Vitro

Clathrodin (10 mM) reduces the mean maximum amplitude of inward sodium currents by 30% in cells isolated from embryonic chicken sympathetic ganglia^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 135383-64-1
분자량 231.25
화학식 C₁₁H₁₃N₅O
SMILES

O=C(NC/C=C/C1=CN=C(N1)N)C2=CC=CN2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zidar N, et al. Antimicrobial activity of the marine alkaloids, clathrodin and oroidin, and their synthetic analogues. Marine drugs. 2014 Feb 14;12(2):940-63.

[2]. Lillsunde KE, et al. Marine alkaloid oroidin analogues with antiviral potential: A novel class of synthetic compounds targeting the cellular chaperone Hsp90. Chemical biology & drug design. 2017 Dec;90(6):1147-1154.

[3]. Peigneur S, et al. Action of clathrodin and analogues on voltage-gated sodium channels. Marine drugs. 2014 Apr 04;12(4):2132-43.

[4]. Zidar N, et al. Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. European journal of medicinal chemistry. 2017 Oct 20;139:232-241. [Content Brief]

[5]. Hodnik Ž, et al. Novel state-dependent voltage-gated sodium channel modulators, based on marine alkaloids from Agelas sponges. European journal of medicinal chemistry. 2013;70:154-64.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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