Clomesone
Clomesone (NSC 338947) is a compound with antitumor activity. Clomesone induces the formation of cross-links between DNA strands in cell lines. Clomesone is inactive against most human colorectal cancer solid tumor cell lines in vitro, has no significant activity against mouse tumors in vivo, and is accompanied by bone marrow suppression. Its pharmacokinetic behavior indicates that it cannot reach effective concentrations at the tumor site.
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- CAS No.: 88343-72-0
- 화학식: C4H9ClO5S2
- 분자량:236.69
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
3 μM
Compound: 10
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In vitro growth inhibition against L1210 murine leukemia cells
In vitro growth inhibition against L1210 murine leukemia cells
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[PMID: 2342050] |
Chemical Information
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CAS No. 88343-72-0
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분자량 236.69
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화학식 C4H9ClO5S2
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SMILES
O=S(OCCCl)(CS(=O)(C)=O)=O
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Synonyms
NSC 338947; CIEtSoSo
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Pre-clinical evaluation of a novel chloroethylating agent, Clomesone [Content Brief]
[2]. M E Dolan, et al. Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate. Cancer Res. 1988 Jul 1;48(13):3603-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Clomesone Related Classifications
HY-W848341 Related Classifications
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