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Dalotuzumab

(Synonyms: MK-0646; h7C10)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo.

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  • Experimental Validation Results for Dalotuzumab
  • Experimental Validation Results for Dalotuzumab
  • Experimental Validation Results for Dalotuzumab
  • Dalotuzumab Chemical Structure
    Dalotuzumab Chemical Structure
CAS No.: 1005389-60-5
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주변의 대리점 찾기 Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Human IGF1R Protein (ECD, His Tag) can bind Dalotuzumab. The EC50 for this effect is 0.98 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 MCF-7 cells with Dalotuzumab (HY-P99284, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control.

  • Dalotuzumab Chemical Structure
    1/16
  • Dalotuzumab
  • Immobilized Human IGF1R Protein (ECD, His Tag) can bind Dalotuzumab. The EC50 for this effect is 0.98 ng/mL.
  • Flow cytometric analysis of 1X106 MCF-7 cells with Dalotuzumab (HY-P99284, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control.