DEG-35
Based on 1 Customer Validation
DEG-35 is a CRBN-dependent, dual IKZF2 and CK1α molecule glue degrader, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. DEG-35 activates the p53 apoptosis pathway. DEG-35 can be used in the research for Acute Myeloid Leukemia (AML).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.88%
- CAS No.: 2734910-37-1
- 화학식: C25H21N3O5
- 분자량:443.45
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | EC50 |
12 nM
Compound: 35; DEG-35
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Cytotoxicity against human A2780 cells incubated for 5 days by MTT assay
Cytotoxicity against human A2780 cells incubated for 5 days by MTT assay
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[PMID: 38085607] |
| NCI-H1048 | EC50 |
49 nM
Compound: 35; DEG-35
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Cytotoxicity against human NCI-H1048 cells incubated for 5 days by MTT assay
Cytotoxicity against human NCI-H1048 cells incubated for 5 days by MTT assay
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[PMID: 38085607] |
| OCI-Ly3 | EC50 |
8 nM
Compound: 35; DEG-35
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Cytotoxicity against human OCILY3 cells incubated for 5 days by MTT assay
Cytotoxicity against human OCILY3 cells incubated for 5 days by MTT assay
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[PMID: 38085607] |
In Vitro
In Vivo
DEG-35 (ip, 50 mg/kg) delays leukemia progression in BL/6 mice transplanted with MLL-AF9 CrbnI391V cells, without overt weight loss[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2734910-37-1
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Appearance Solid
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분자량 443.45
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화학식 C25H21N3O5
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Color White to off-white
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SMILES
COC1=CC2=C(C=C(C=C2)C(NC3=CC4=C(C(N(C4)C5CCC(NC5=O)=O)=O)C=C3)=O)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DEG-35 Related Classifications
HY-172931 Related Classifications
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