Demethoxycurcumin-d4
Based on 1 Customer Validation
Demethoxycurcumin-d4 is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin (Curcumin II) is a major active curcuminoid; possess anti-inflammatory properties.
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- Purity: 98.89%
- 화학식: C20H14D4O5
- 분자량:342.38
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 22608-11-3
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Appearance Solid
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분자량 342.38
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화학식 C20H14D4O5
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Color Orange to red
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SMILES
O=C(CC(/C=C/C1=C([2H])C([2H])=C(O)C([2H])=C1[2H])=O)/C=C/C2=CC=C(O)C(OC)=C2
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Synonyms
Curcumin II-d4; Desmethoxycurcumin-d4; Monodemethoxycurcumin-d4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (292.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (269 KB)
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SDS (399 KB)
- English - EN (399 KB)
- Français - FR (399 KB)
- Deutsch - DE (399 KB)
- Norwegian - NO (399 KB)
- Español - ES (399 KB)
- Swedish - SV (399 KB)
- Italian - IT (399 KB)
- Korean - KR (399 KB)
- Portuguese - PT (399 KB)
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Handling Instructions (2659 KB)
References
[1]. Somchit M, et al. Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev. 2014;15(4):1807-10. [Content Brief]
[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9207 mL | 14.6037 mL | 29.2073 mL | 73.0183 mL |
| 5 mM | 0.5841 mL | 2.9207 mL | 5.8415 mL | 14.6037 mL | |
| 10 mM | 0.2921 mL | 1.4604 mL | 2.9207 mL | 7.3018 mL | |
| 15 mM | 0.1947 mL | 0.9736 mL | 1.9472 mL | 4.8679 mL | |
| 20 mM | 0.1460 mL | 0.7302 mL | 1.4604 mL | 3.6509 mL | |
| 25 mM | 0.1168 mL | 0.5841 mL | 1.1683 mL | 2.9207 mL | |
| 30 mM | 0.0974 mL | 0.4868 mL | 0.9736 mL | 2.4339 mL | |
| 40 mM | 0.0730 mL | 0.3651 mL | 0.7302 mL | 1.8255 mL | |
| 50 mM | 0.0584 mL | 0.2921 mL | 0.5841 mL | 1.4604 mL | |
| 60 mM | 0.0487 mL | 0.2434 mL | 0.4868 mL | 1.2170 mL | |
| 80 mM | 0.0365 mL | 0.1825 mL | 0.3651 mL | 0.9127 mL | |
| 100 mM | 0.0292 mL | 0.1460 mL | 0.2921 mL | 0.7302 mL |
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