Donidalorsen
Based on 1 Customer Validation
Donidalorsen (ISIS-721744; IONIS-PKK-LRX free acid) is an antisense oligonucleotide targeting prekallikrein (PKK). Donidalorsen inhibits kallikrein activity and reduces the production of Bradykinin (HY-P0206) by specifically binding to and degrading PKK mRNA in the liver. Donidalorsen can be used in the research of hereditary angioedema.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.39%
- CAS No.: 2304692-48-4
- 화학식: C296H435N83O151P20S15
- 분자량:8672.64
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
Donidalorsen binds selectively to hepatic prekallikrein mRNA, mediates its degradation via ribonuclease H1, reduces hepatic prekallikrein production, reduces plasma prekallikrein concentrations, reduces plasma D-dimer concentrations, inhibits prekallikrein protein production, and reduces hereditary angioedema attack frequency[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2304692-48-4
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Appearance Solid
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분자량 8672.64
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화학식 C296H435N83O151P20S15
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Color White to off-white
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SMILES
[Donidalorsen]
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Synonyms
ISIS-721744 free acid; IONIS-PKK-LRX free acid
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
순도&문서
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Data Sheet (265 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2242 KB)
References
[1]. Petersen RS, et al. A phase 2 open-label extension study of prekallikrein inhibition with donidalorsen for hereditary angioedema. Allergy. 2024;79(3):724-734. [Content Brief]
[2]. Diep JK, et al. Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema. CPT Pharmacometrics Syst Pharmacol. 2026;15(2):e70206. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)