ELB041
ELB041 (AFS98) is a rat monoclonal anti-murine c-fms antibody (IgG2a). AFS98 inhibits M-CSF–dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor. AFS98 prevents development of fatty streaks in ApoE-deficient mice. ELB041 can be used for the research of atherosclerosis.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Species Reactivity
Human
IC50 & Target
CSF1R/M-CSFR/CD115
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Apolipoprotein E (apoE)-deficient mice (female, 6 weeks of age, hybrid 129ola x C57BL/6)[1]
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Dosage:2 mg
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Administration:i.p.; alternate days; 6 weeks
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Result:Suppressed macrophage-derived foam cell accumulation in the aortic root by ~70% (total aortic lesion area: 2390 ± 204 μm² vs. PBS control: ~9000 μm²). Had minimal effect on advanced lesion size (AFS98 group: 30728 ± 2248 μm² vs. PBS group: 31753 ± 17483 μm²). Did not reduce macrophage or vascular smooth muscle cell staining in lesions. Did not significantly reduce peripheral blood monocyte count or body weight.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
신청
ELISA, FACS, Functional assay
Chemical Information
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Synonyms
AFS98; TG3003
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ELB041 Related Classifications
HY-P991947 Related Classifications
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Keywords
- ELB041
- AFS98
- TG3003
- ELB 041
- ELB-041
- AFS 98
- AFS-98
- TG3003
- TG 3003
- TG-3003
- c-Fms
- fatty streak lesion development
- cell growth
- c-fms
- vessel wall intima
- high-fat diet
- atherosclerosis
- aortic root
- apoE-deficient mice
- advanced atherosclerotic lesion size
- M-CSF
- macrophage-derived foam cells
- monocyte/macrophage
- early atherosclerotic fatty streak formation
- M-CSF-dependent colony formation
- Inhibitor
- inhibitor
- inhibit