Epobis
Based on 1 Customer Validation
Epobis, a dendrimeric peptide, is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties.
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- Purity: 99.38%
- CAS No.: 915091-83-7
- 화학식: C100H151N27O29
- 분자량:2195.44
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Epobis (0-8.82 μM) stimulates neurite outgrowth from motor neurons in a dose-dependent manner with maximal stimulation at 0.33 μM[1].
Epobis (0-8.82 μM; 24 h) reduces release of TNF and improves the survival of the L929 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L929 cells
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Concentration:0-8.82 μM
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Incubation Time:24 hours
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Result:Had a significantly higher viability of 64% in a concentration of 8.4 μM, whereas the highest viability (68%) in a concentration of 2.7 μM.
Epobis (10 mg/kg; i.h.) has an anti-inflammatory effect in mice of multiple sclerosis model[1].
Epobis (10 mg/kg; i.h.; old (>18 month) rats and in rats experiencing early stage AD) improves social memory[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (200 g)[1]
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Dosage:10 mg/kg
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Administration:Subcutaneous injection; once
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Result:Had detectable already 15 min after administration and remained detectable in the blood for at least 24 h.
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Animal Model:Wistar rats with multiple sclerosis model (200 g)[1]
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Dosage:10 mg/kg
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Administration:Subcutaneous injection; once
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Result:Had no significant effects on the weight changes or the survival of experimental autoimmune encephalomyelitis (EAE) animals.
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Animal Model:Old (>18 month) rats and in rats experiencing early stage AD[1]
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Dosage:10 mg/kg
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Administration:Subcutaneous injection; once
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Result:Had significantly lower than that of vehicle-treated animals.
Chemical Information
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CAS No. 915091-83-7
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Appearance Solid
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분자량 2195.44
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화학식 C100H151N27O29
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Color White to off-white
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Sequence Shortening
NENITVPDTKVNFYAWKR
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
H2O : ≥ 50 mg/mL (22.77 mM)
DMSO : 4 mg/mL (1.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (270 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 0.4555 mL | 2.2774 mL | 4.5549 mL | 11.3872 mL |
| H2O | 5 mM | 0.0911 mL | 0.4555 mL | 0.9110 mL | 2.2774 mL |
| 10 mM | 0.0455 mL | 0.2277 mL | 0.4555 mL | 1.1387 mL | |
| 15 mM | 0.0304 mL | 0.1518 mL | 0.3037 mL | 0.7591 mL | |
| 20 mM | 0.0228 mL | 0.1139 mL | 0.2277 mL | 0.5694 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Epobis Related Classifications
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