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United States

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Cat. No.: HY-153399

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Fosigotifator

(Synonyms: ABBV-CLS-7262)

Fosigotifator (ABBV-CLS-7262) is a brain penetrant, orally active EIF2b (eukaryotic initiation factor) activator. Fosigotifator stabilizes the elF2B complex and boosts the activity, including that of complexes carrying pathogenic vanishing white matter (VWM) mutations. Fosigotifator is an integrated stress response inhibitor (ISRI). Fosigotifator can be used for amyotrophic lateral sclerosis research.

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CAS No.: 2415715-84-1
화학식: C₂₅H₂₇Cl₂F₂N₂O₉P
분자량:639.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Fosigotifator Chemical Structure

CAS No.: 2415715-84-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

Fosigotifator improves motor dysfunction in a VWM mouse model. Simultaneously, integrated stress response (ISR) gene expression and pharmacodynamic biomarkers also underwent corresponding changes. Furthermore, neurofilament light chain (NfL) levels are significantly reduced in VWM mice treated with Fosigotifator^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2415715-84-1
분자량 639.37
화학식 C₂₅H₂₇Cl₂F₂N₂O₉P
SMILES

O=C(COC(C=C1)=CC(F)=C1Cl)NC(CCC23NC(COC(C=C4)=CC(F)=C4Cl)=O)(CC2)[C@H](C3)OCO[P](O)(O)=O
Synonyms

ABBV-CLS-7262
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Michael Hayden, et al. Method of treating amyotrophic lateral sclerosis with pridopidine. US20230190724 A1. 2023.6.22.

[2]. Amos Baruch, et al. Development of eIF2B Activator ABBV-CLS-7262 as a Novel Treatment for Vanishing White Matter Disease (P2-8.001). Neurology. Volume 102 Number 7 April 09,2024

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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