Pacsin1 - protein kinase C and casein kinase substrate in neurons 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29704

Summary

Enables phospholipid binding activity. Involved in several processes, including plasma membrane tubulation; positive regulation of dendrite development; and regulation of postsynaptic neurotransmitter receptor internalization. Located in axon terminus; perinuclear region of cytoplasm; and plasma membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human PACSIN1 (protein kinase C and Casein Kinase substrate in neurons 1). [provided by Alliance of Genome Resources, Apr 2022]

Pacsin1 Products (1)

mRNA	Protein	Name
NM_017294.1	NP_058990.1	protein kinase C and casein kinase substrate in neurons protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phospholipid binding	IDA IDA: Inferred from direct assay	22355135	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9950691	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cytoskeleton organization	IDA IDA: Inferred from direct assay	9950691	RGD
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	22355135	RGD
involved in plasma membrane tubulation	IMP IMP: Inferred from mutant phenotype	22355135	RGD
involved in positive regulation of dendrite development	IDA IDA: Inferred from direct assay	21725280	RGD
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	21725280	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	16617342	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	16617342	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon terminus	IDA IDA: Inferred from direct assay	22355135	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16617342	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16617342	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21725280	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	21725280	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	16617342	RGD
located in synapse	IDA IDA: Inferred from direct assay	21725280	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein kinase C and casein kinase substrate in neurons protein 1	dynamin PRD-interacting protein dynamin proline-rich domain-interacting protein sdpI synaptic, dynamin-associated protein I syndapin-1 syndapin-I

Pacsin1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Pacsin1	Q9Z0W5	Cobl	Mus musculus	Q5NBX1	Pull Down	21725280
Cross	Pacsin1	Q9Z0W5	Cobl	Mus musculus	Q5NBX1	Y2H	17956734
Intra	Pacsin1	Q9Z0W5	Cobl	Rattus norvegicus	D3ZUI5	Anti Bait CoIP	21725280
Intra	Pacsin1	Q9Z0W5	Cobl	Rattus norvegicus	D3ZUI5	Density Sedimentation	21725280
Cross	Pacsin1	Q9Z0W5	NCKIPSD	Homo sapiens	Q9NZQ3	Y2H	16999739
Cross	Pacsin1	Q9Z0W5	NCKIPSD	Homo sapiens	Q9NZQ3	Anti Bait CoIP	16999739
Cross	Pacsin1	Q9Z0W5	NCKIPSD	Homo sapiens	Q9NZQ3	Pull Down	16999739
Intra	Pacsin1	Q9Z0W5	Dnm1	Rattus norvegicus	P21575	Anti Bait CoIP	17437541

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS09957	PACSIN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19839	Pacsin1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26336	Pacsin1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pacsin1	NCBI	NCBI:29993