country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

PSMC3 - proteasome 26S subunit, ATPase 3 Gene

Also Known as RPT5; TBP1; DCIDP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5702

About PSMC3

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,418,775-47,426,439 (from NCBI)

This gene has 13 transcripts (splice variants), 220 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 35.4), brain (RPKM 35.2) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

PSMC3 Products (1)

mRNA	Protein	Name
NM_002804.5	NP_002795.2	26S proteasome regulatory subunit 6A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in modulation by host of viral transcription	IDA IDA: Inferred from direct assay	2194290	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19853614	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	2194290	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	9464850	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMC3 Protein Structure

AAA

0
100
200
300
400
439 a.a.

Protein Preferred Names	Protein Names
26S proteasome regulatory subunit 6A	26S protease regulatory subunit 6A

PSMC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PSMC3	P17980	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Array	25416956
Intra	PSMC3	P17980	CKMT1A	Homo sapiens	P12532	Y2H Array	32296183
Intra	PSMC3	P17980	CKMT1A	Homo sapiens	P12532	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	NDUFAB1	Homo sapiens	O14561	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	NDUFAB1	Homo sapiens	O14561	Y2H Array	32296183
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Y2H Prey Pooling	25416956
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	35271311
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	28514442
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Anti Tag CoIP	19490896
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Validated Y2H	25416956
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Validated Y2H	32296183
Intra	PSMC3	P17980	PSMC6	Homo sapiens	P62333	Y2H Array	25416956
Intra	PSMC3	P17980	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Anti Tag CoIP	19490896
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Array	31515488
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Prey Pooling	25416956
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Array	25416956
Intra	PSMC3	P17980	TRAF4	Homo sapiens	Q9BUZ4	Anti Tag CoIP	28514442
Intra	PSMC3	P17980	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	PSMC3	P17980	TRAF4	Homo sapiens	Q9BUZ4	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PSMC3	P17980	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PSMC3	P17980	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Validated Y2H	32296183
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Y2H Array	32296183
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Anti Tag CoIP	28514442
Intra	PSMC3	P17980	FBXO28	Homo sapiens	Q9NVF7	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	DPY30	Homo sapiens	Q9C005	Validated Y2H	32296183
Intra	PSMC3	P17980	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	PSMC3	P17980	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	PSMC3	P17980	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Anti Tag CoIP	35271311
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Prey Pooling	32296183
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Anti Tag CoIP	33961781
Intra	PSMC3	P17980	PSMD9	Homo sapiens	O00233	Y2H Array	32296183
Intra	PSMC3	P17980	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	PSMC3	P17980	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	PSMC3	P17980	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	PSMC3	P17980	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	PSMC3	P17980	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	PSMC3	P17980	SNCA	Homo sapiens	P37840	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

PSMC3 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P84142	PSMC3 Antibody (YA3839)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Monkey
HY-P84142A	PSMC3 Antibody (YA3839)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Monkey

Related Diseases

Diseases	Alias
Deafness, Cataract, Impaired Intellectual Development, And Polyneuropathy	DCIDP
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Polyneuropathy	Polyneuropathies
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS11312	PSMC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11313	PSMC3IP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PSMC3	MGD	MGI:1098754
Rattus norvegicus	PSMC3	RGD	RGD:61905
Macaca mulatta	PSMC3	VGNC	VGNC:101385
Felis catus	PSMC3	VGNC	VGNC:69113
Bos taurus	PSMC3	VGNC	VGNC:33456
Others	PSMC3	NCBI