SST - somatostatin Gene
Also Known as SMST; SST1
Species: Homo sapiens
About SST
This gene has 1 transcript (splice variant) and 195 orthologues. Biased expression in stomach (RPKM 141.6), duodenum (RPKM 136.3) and 5 other tissues.
Summary
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary Hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most Hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]
SST Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001048.4 | NP_001039.1 | somatostatin preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
15247250 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
28650319 | GOA |
SST Protein Structure
Somatostatin: Somatostatin/Cortistatin family (99 - 116)
- 0
- 100
- 116 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
somatostatin |
|
SST Antibodies
| Cat. No. | 상품명 | 신청 | Reactivity |
|---|---|---|---|
| HY-P84423 | Somatostatin Antibody (YA4120) | IHC-P, FC, ELISA | Human, Mouse, Rat |
| HY-P84423A | Somatostatin Antibody (YA4120)(PBS only) | IHC-P, FC, ELISA | Human, Mouse, Rat |
| HY-P85983 | Somatostatin Antibody (YA5675) | IHC-P, ICC/IF, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Somatostatinoma |
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| Acromegaly |
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| Vipoma |
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| Esophageal Varix |
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| Glucagonoma |
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| Dumping Syndrome |
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| Islet Cell Tumor |
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| Neuroendocrine Tumor |
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| Chylothorax, Congenital |
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| Gastrinoma |
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| Zollinger-Ellison Syndrome |
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| Insulinoma |
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| Prolactinoma |
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| Portal Hypertension |
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| Growth Hormone Secreting Pituitary Adenoma |
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| Nelson Syndrome |
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| Duodenal Ulcer |
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| Short Bowel Syndrome |
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| Neuroendocrine Carcinoma |
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| Pancreatic Endocrine Carcinoma |
|
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| Cholelithiasis |
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| Conn'S Syndrome |
|
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| Acute Pancreatitis |
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| Hyperinsulinism |
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| Multiple Endocrine Neoplasia, Type I |
|
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| Endocrine Gland Cancer |
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| Ascites, Chylous |
|
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| Paraganglioma |
|
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| Pituitary-Dependent Cushing'S Disease |
|
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| Gastrointestinal Neuroendocrine Tumor |
|
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| Duodenal Somatostatinoma |
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| Hyperpituitarism |
|
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| Pituitary Tumors |
|
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| Cryptosporidiosis |
|
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| Pancreatic Somatostatinoma |
|
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| Hyperprolactinemia |
|
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| Pituitary Gland Disease |
|
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| Small Intestine Benign Neoplasm |
|
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| Hyperthyroidism |
|
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| Carcinoid Syndrome |
|
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| Pernicious Anemia |
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| Adenoma |
|
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| Pancreatitis |
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| Pituitary Adenoma |
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| Duodenogastric Reflux |
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| Hormone Producing Pituitary Cancer |
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| Bronchial Adenomas/Carcinoids Childhood |
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| Pituitary Cancer |
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| Pertussis |
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| Pancreatic Cholera |
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| Carcinoid Tumors, Intestinal |
|
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| Hypoglycemia |
|
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| Pancreatic Cystadenoma |
|
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| Hyperglycemia |
|
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| Pheochromocytoma |
|
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| Serotonin Syndrome |
|
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| Postgastrectomy Syndrome |
|
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| Endocrine Pancreas Disease |
|
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| Pyloric Stenosis |
|
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| Subependymal Giant Cell Astrocytoma |
|
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| Pancreatic Cancer |
|
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| Ampulla Of Vater Benign Neoplasm |
|
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| Thyroid Carcinoma, Familial Medullary |
|
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| Duodenal Benign Neoplasm |
|
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| Fibrous Dysplasia |
|
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| Ganglioneuroma |
|
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| Liver Cirrhosis |
|
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| Functioning Pituitary Adenoma |
|
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| Gastric Ulcer |
|
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| Hyperinsulinemic Hypoglycemia, Familial, 2 |
|
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| Gastrointestinal Neuroendocrine Benign Tumor |
|
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| Ectopic Cushing Syndrome |
|
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| Pituitary Adenoma 1, Multiple Types |
|
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| Klippel-Trenaunay-Weber Syndrome |
|
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| Microvascular Complications Of Diabetes 1 |
|
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| Type 1 Diabetes Mellitus |
|
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| Multiple Endocrine Neoplasia |
|
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| Hepatic Encephalopathy |
|
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| Atrophic Gastritis |
|
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| Constipation |
|
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| Pancreatic Gastrinoma |
|
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| Sudden Infant Death Syndrome |
|
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| Benign Ileal Neoplasm |
|
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| Diarrhea |
|
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| Gastroparesis |
|
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| Duodenal Gastrinoma |
|
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| Status Epilepticus |
|
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| Small Intestine Neuroendocrine Neoplasm |
|
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| Chiasmal Syndrome |
|
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| Gastric Neuroendocrine Neoplasm |
|
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| Pulmonary Neuroendocrine Tumor |
|
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| Goiter |
|
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| Merkel Cell Carcinoma |
|
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| Pituitary Infarct |
|
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| Non-Functioning Pancreatic Endocrine Tumor |
|
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| Thyroid Gland Cancer |
|
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| Tsh Producing Pituitary Tumor |
|
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| Duodenum Disease |
|
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| Small Cell Cancer Of The Lung |
|
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| Meningioma, Familial |
|
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| Gastritis |
|
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| Irritable Bowel Syndrome |
|
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| Jejunal Somatostatinoma |
|
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| Duodenum Cancer |
|
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| Endocrine Organ Benign Neoplasm |
|
|
| Weber Syndrome |
|
|
| Acute Hemorrhagic Pancreatitis |
|
|
| Thyroid Hormone Resistance, Selective Pituitary |
|
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| Cystinosis |
|
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| Glucose Intolerance |
|
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| Angiodysplasia |
|
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| Thyroid Gland Medullary Carcinoma |
|
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| Anal Neuroendocrine Tumor |
|
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| Yellow Nail Syndrome |
|
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| Neurofibromatosis, Type I |
|
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| Tuberous Sclerosis |
|
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| Esophageal Neuroendocrine Tumor |
|
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| Cholangitis |
|
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| Biliary Dyskinesia |
|
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| Colon Neuroendocrine Neoplasm |
|
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| Peptic Ulcer Disease |
|
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| Hepatic Vascular Disease |
|
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| Functional Gastric Disease |
|
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| Intestinal Pseudo-Obstruction |
|
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| Optic Nerve Sheath Meningioma |
|
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| Hyperinsulinemic Hypoglycemia |
|
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| Insulin-Like Growth Factor I |
|
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| Vein Disease |
|
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| Tetanus |
|
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| Obsessive-Compulsive Disorder |
|
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| Skull Base Meningioma |
|
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| Skull Base Cancer |
|
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| Acidophil Adenoma |
|
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| Teratoma |
|
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| Diabetes Mellitus |
|
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| Adrenal Carcinoma |
|
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| Acth-Secreting Pituitary Adenoma |
|
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| Adrenal Gland Disease |
|
|
| Functionless Pituitary Adenoma |
|
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| Pituitary Apoplexy |
|
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| Large Cell Neuroendocrine Carcinoma |
|
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| Tricuspid Valve Stenosis |
|
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| Malignant Pheochromocytoma |
|
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| Adrenal Medulla Cancer |
|
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| Hypothyroidism |
|
|
| Gastrointestinal System Benign Neoplasm |
|
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| Esophageal Atresia |
|
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| Functional Colonic Disease |
|
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| Secretory Diarrhea |
|
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| Lissencephaly, X-Linked, 2 |
|
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| Gastric Hemangioma |
|
|
| Active Peptic Ulcer Disease |
|
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| Intracranial Meningioma |
|
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| Polycystic Liver Disease |
|
|
| Gastritis, Familial Giant Hypertrophic |
|
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| Transient Refractive Change |
|
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| Pulmonary Valve Insufficiency |
|
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| Meckel Diverticulum |
|
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| Lymphocele |
|
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| Rett Syndrome |
|
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| Narcolepsy |
|
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| Articulation Disorder |
|
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| Duodenal Obstruction |
|
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| Huntington Disease |
|
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| Optic Nerve Neoplasm |
|
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| Cholecystolithiasis |
|
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| Hemopneumothorax |
|
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| Colonic Pseudo-Obstruction |
|
|
| Gangliocytoma |
|
|
| Gastric Gastrinoma |
|
|
| Rectum Neuroendocrine Neoplasm |
|
|
| Lung Large Cell Carcinoma |
|
|
| Common Bile Duct Neoplasm |
|
|
| Peripheral Nervous System Benign Neoplasm |
|
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| Autonomic Nervous System Benign Neoplasm |
|
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| Acute Necrotizing Pancreatitis |
|
|
| Cell Type Benign Neoplasm |
|
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| Thyroid Gland Disease |
|
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| Duodenitis |
|
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| Anxiety |
|
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| Cranial Nerve Malignant Neoplasm |
|
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| Heart Disease |
|
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| Brain Meningioma |
|
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| Obstructive Jaundice |
|
|
| Stuttering |
|
|
| Myasthenic Syndrome, Congenital, 11, Associated With Acetylcholine Receptor Deficiency |
|
|
| Mccune-Albright Syndrome |
|
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| Thyroid Dyshormonogenesis 2a |
|
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| Gallbladder Disease |
|
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| Von Hippel-Lindau Syndrome |
|
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| Endometrial Small Cell Carcinoma |
|
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| Carney Complex Variant |
|
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| Colorectal Cancer |
|
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| Dystonia |
|
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| Autosomal Dominant Polycystic Kidney Disease |
|
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| Perianal Hematoma |
|
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| Epilepsy |
|
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| Major Depressive Disorder |
|
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| Neuroblastoma |
|
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| Speech Disorder |
|
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| Type 2 Diabetes Mellitus |
|
|
| Abnormality Of Glucagon Secretion |
|
|
| Schizophrenia |
|
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| Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease |
|
|
| Maturity-Onset Diabetes Of The Young |
|
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| Inflammatory Bowel Disease |
|
|
| Prostate Cancer |
|
|
| Cystic Kidney Disease |
|
|
| Hypertension, Essential |
|
|
| Patent Foramen Ovale |
|
|
| Breast Cancer |
|
|
| Polycystic Kidney Disease |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Developmental And Epileptic Encephalopathy |
|
|
| Peripheral Nervous System Disease |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | SST | VGNC | VGNC:35324 |
| Rattus norvegicus | SST | RGD | RGD:3761 |
| Canis familiaris | SST | VGNC | VGNC:46842 |
| Felis catus | SST | VGNC | VGNC:102851 |
| Mus musculus | SST | MGD | MGI:98326 |
| Macaca mulatta | SST | VGNC | VGNC:77892 |
| Others | SST | NCBI |