country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-185334

Copy Link Print Information

GNE-3565

GNE-3565 is an arylsulfonamide class Na_V1.7 inhibitor with subnanomolar channel blockage and mixed subtype selectivity.GNE-3565 can be used for the research of pain.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2222537-72-4
화학식: C₂₅H₂₆ClF₄N₅O₂S
분자량:572.02

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

GNE-3565 Chemical Structure

CAS No.: 2222537-72-4

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

GNE-3565 is an arylsulfonamide class Na_V1.7 inhibitor with subnanomolar channel blockage and mixed subtype selectivity.GNE-3565 can be used for the research of pain^[1].

All Sodium Channel Isoforms :

In Vitro

GNE-3565 (50 μM; 10 min at 22 °C) binds to the VSD4 domain of the VSD4-NaV1.7-NaVPas chimeric channel in a pose similar to the arylsulfonamide inhibitor GX-936, forming key interactions with the R4 gating charge and subtype-selectivity residues Tyr1537 and Trp1538^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2222537-72-4
분자량 572.02
화학식 C₂₅H₂₆ClF₄N₅O₂S
SMILES

CN(C)[C@@H](C[C@@H](C1=CC(C(F)(F)F)=CC=C1)CC2)[C@H]2NC3=C(C=C(C(F)=C3)S(NC4=NC=NC=C4)(=O)=O)Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kschonsak M, et al. Cryo-EM reveals an unprecedented binding site for Na_V1.7 inhibitors enabling rational design of potent hybrid inhibitors. Elife. 2023;12:e84151. Published 2023 Mar 28. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

GNE-3565

All Sodium Channel Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GNE-3565 Related Classifications

HY-185334 Related Classifications