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Cat. No.: HY-A0104

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HPMC (Viscosity:11250-21000mPa.s)

(Synonyms: Hypromellose (Viscosity:11250-21000mPa.s); (Hydroxypropyl)methyl cellulose (Viscosity:11250-21000mPa.s); Celacol HPM 5000 (Viscosity:11250-21000mPa.s))

3 Cited Publications

고객리뷰

Based on 3 publication(s) in Google Scholar

HPMC (Viscosity:11250-21000mPa.s) is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 9004-65-3

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

HPMC (Viscosity:11250-21000mPa.s) Chemical Structure

CAS No.: 9004-65-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
Publications (3)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

HPMC (Viscosity:11250-21000mPa.s) is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices.

In Vitro

Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect^[1]. Hypromellose (hydroxypropylmethylcellulose) has been used in sustained-release pharmaceutical products for many years. When used in matrix tablets, these polymers hydrate on contact with water to produce a viscous gel barrier within and surrounding the tablet. The properties of hypromellose that affect the rate of drug release include the rate of diffusion of water into the dry polymer, the rate of hypromellose hydration and gel formation, the viscosity of the hydrated hypromellose and rate of hypromellose gel erosion^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Punctal occlusion using hypromellose 2% is a low-cost and safe additional treatment for dry eye. Fluorescein and rose bengal staining tests show that there was a significant reduction in signs after occlusion using hypromellose^[3]. Hypromellose is effective in improving the blood glucose metabolism and suppressing oxidative stress in mice fed with a high fat diet. The antihyperglycemic and antioxidative effects of hypromellose could be partly attributed to the regulation of hepatic glucose-regulating enzyme activities and activation of the hepatic and erythrocyte antioxidant enzymes. Hypromellose may be useful as biomaterials in the development of functional food or as therapeutic agents against high fat-induced hyperglycemia and oxidative stress^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 9004-65-3
Appearance Solid
Color White to off-white
SMILES

[R]O[C@@H]1[C@H](O[R])[C@@H](O[R])[C@H](O[C@H]2[C@H](O[R])[C@@H](O[R])[C@H](O[R])[C@@H](CO[R])O2)[C@@H](CO[R])O1.CO.CC(O)CO.[n].[x]
Synonyms

Hypromellose (Viscosity:11250-21000mPa.s); (Hydroxypropyl)methyl cellulose (Viscosity:11250-21000mPa.s); Celacol HPM 5000 (Viscosity:11250-21000mPa.s)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Journal Impact Factor

Cancer Cell

Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. [Abstract]

2021 Mar 8;39(3):423-437.e7. PMID: 33450198
Nat Commun

ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. [Abstract]

2023 May 19;14(1):2859. PMID: 37208329
Oncogene

MUC1 triggers lineage plasticity of Her2 positive mammary tumors. [Abstract]

2022 May;41(22):3064-3078. PMID: 35461328

용액&용해도

In Vitro:

DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 10 mg/mL (Need ultrasonic)

View the Complete Stock Solution Preparation Table

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 8.33 mg/mL; Clear solution; Need ultrasonic and warming and heat to 60°C

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li CL, et al. The use of hypromellose in oral drug delivery. J Pharm Pharmacol. 2005 May;57(5):533-46. [Content Brief]

[2]. Braund R, et al. Hypromellose films for the delivery of growth factors for wound healing. [Content Brief]

[3]. Capita L, et al. Prospective evaluation of hypromellose 2% for punctal occlusion in patients with dry eye. Cornea. 2015 Feb;34(2):188-92. [Content Brief]

[4]. Ban SJ, et al. Antihyperglycemic and antioxidative effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in mice fed with a high fat diet. Int J Mol Sci. 2012;13(3):3738-50. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

HPMC (Viscosity:11250-21000mPa.s)

3 Cited Publications

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Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
Publications (3)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References

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HPMC (Viscosity:11250-21000mPa.s)

Publications Citing Use of MedChemExpress (MCE) HPMC (Viscosity:11250-21000mPa.s)

Biological Activity

Chemical Information

Publications (3)

용액&용해도

순도&문서

References

Calculators

Help & FAQs

HPMC (Viscosity:11250-21000mPa.s) Related Classifications

HY-A0104 Related Classifications