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Cat. No.: HY-P10792A

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HYNIC-H6F

HYNIC-H6F is a SPECT imaging probe with binding specificity for human epidermal growth factor receptor 2 (HER2) domain II (IC₅₀ = 11 nM). HYNIC-H6F accumulates in HER2-positive breast cancer xenografts via receptor-mediated uptake, while shows low uptake in HER2-negative breast cancer xenografts. HYNIC-H6F enables non-invasive detection of HER2-positive breast cancer in mouse models and allows evaluation of HER2 expression levels without blocking interference. HYNIC-H6F can be used in breast cancer-related research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₆₄H₈₂N₁₄O₁₃
분자량:1255.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

맞춤형 펩타이드 합성

HYNIC-H6F Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

HER2

11 nM (IC₅₀)

All EGFR Isoforms :

In Vitro

HYNIC-H6F (11 nM; 2 h) binds specifically to HER2 on MDA-MB-453 cells with an IC₅₀ of 11 nM, with minimal impact on binding affinity from HYNIC conjugation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

99mTc-HYNIC-H6F (0.37-37 MBq; i.v. via tail vein; single dose) specifically accumulates in HER2-positive MDA-MB-453 breast cancer xenografts, reaching a peak imaging-quantified uptake of 3.58 %ID/g at 30 min after injection, with binding blocked by excess unlabeled H6F^[1].
99mTc-HYNIC-H6F (0.37-37 MBq; i.v. via tail vein; single dose) exhibits minimal accumulation in HER2-negative MDA-MB-231 breast cancer xenografts, with a biodistribution-quantified uptake of 0.99 %ID/g at 30 min after injection that is significantly lower than uptake in HER2-positive tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 1255.42
화학식 C₆₄H₈₂N₁₄O₁₃
Sequence

{HYNIC}-Tyr-Leu-Phe-Phe-Val-Phe-Glu-Arg
Sequence Shortening

{HYNIC}-YLFFVFER
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Li L, et al. SPECT/CT imaging of the novel HER2-targeted peptide probe 99mTc-HYNIC-H6F in breast cancer mouse models. Journal of Nuclear Medicine. 2017 May 1;58(5):821-6.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

HYNIC-H6F

All EGFR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HYNIC-H6F Related Classifications

HY-P10792A Related Classifications