I-BOP
I-BOP is an agonist for thromboxane A2 receptor (TP) with a KD of 0.61 nM. I-BOP promotes proliferation through activation of PI3K pathway in vascular smooth muscle. I-BOP dose-dependently biphasicly affects the excitatory postsynaptic potential (e.p.s.p.) in hippocampal neurons.
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- CAS No.: 128719-90-4
- 화학식: C23H29IO5
- 분자량:512.38
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
I-BOP (1-100 nM) activates the MAP kinase, stimulates the tyrosine phosphorylation, and thus causes the activation of PI3K signaling pathway[1].
I-BOP (0.1-3 μM) enhances the synaptic transmission in hippocampal CA1 neuron at low concentration by increasing the neurotransmitter release, inhibits the excitatory synaptic transmission in hippocampal CA1 neuron through reduction of membrane input resistance at high concentration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A7r5.HEL.TP cell
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Concentration:1-100 nM
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Incubation Time:24 h
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Result:Increased phosphorylated tyrosine.
Chemical Information
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CAS No. 128719-90-4
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분자량 512.38
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화학식 C23H29IO5
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SMILES
O=C(O)CCC/C=C\C[C@H]1[C@](O2)([H])CC[C@]2([H])[C@@H]1/C=C/[C@@H](O)COC3=CC=C(I)C=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Morinelli TA, et al., Tyrosine phosphorylation of phosphatidylinositol 3-kinase and of the thromboxane A2 (TXA2) receptor by the TXA2 mimetic I-BOP in A7r5 cells. Biochem Pharmacol. 1997 Jun 15;53(12):1823-32. [Content Brief]
[2]. Hsu KS, et al., Thromboxane A2 agonist modulation of excitatory synaptic transmission in the rat hippocampal slice. Br J Pharmacol. 1996 Aug;118(8):2220-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
I-BOP Related Classifications
HY-116431 Related Classifications
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