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Isatuximab

(Synonyms: ch38SB19; hu38SB19; SAR-650984)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions.

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  • Experimental Validation Results for Isatuximab
  • Experimental Validation Results for Isatuximab
  • Experimental Validation Results for Isatuximab
  • Isatuximab Chemical Structure
    Isatuximab Chemical Structure
CAS No.: 1461640-62-9
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized CD38 Protein, Human can bind Isatuximab. The EC50 for this effect is 6.163 ng/mL.

  • 1/16

    Flow Cytometry analysis of Raji cells labelling CD38 (red) with Isatuximab (anti-CD38) (HY-P9976). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.

  • Isatuximab Chemical Structure
    1/16
  • Isatuximab
  • Immobilized CD38 Protein, Human can bind Isatuximab. The EC50 for this effect is 6.163 ng/mL.
  • Flow Cytometry analysis of Raji cells labelling CD38 (red) with Isatuximab (anti-CD38) (HY-P9976). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.