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Cat. No.: HY-W450772

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JADA3

JADA3 is a molecular glue degrader targeting IKZF1 and IKZF3. JADA3 induces proteasome-mediated degradation of the target transcription factors by binding to the E3 ubiquitin ligase Cereblon. JADA3 can be used in research related to acute myeloid leukemia.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2573901-15-0
화학식: C₁₀H₁₀ClN₃O₂
분자량:239.66

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

JADA3 Chemical Structure

CAS No.: 2573901-15-0

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

IC₅₀ & Target

^[1]

IKZF1

IKZF3

All IKZF Family Isoforms :

In Vitro

JADA3 (0.1-1 μM; 24 h) degrades IKZF1 and IKZF3 proteins in Jurkat cells^[1].
JADA3 binds to CRBN in the CRBN fluorescence polarization (FP) displacement assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Jurkat cells
Concentration:

0.1 and 1 μM
Incubation Time:

24 h
Result:

Induced CRBN-dependent ubiquitination and proteasomal degradation of IKZF1/IKZF3.

Chemical Information

CAS No. 2573901-15-0
분자량 239.66
화학식 C₁₀H₁₀ClN₃O₂
SMILES

O=CC=1C=NN2C(=O)C(=C(Cl)NC12)C(C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. QI J, et al. E3 Ligase Binders and Uses Thereof. WO2020263832A1, 2020.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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JADA3

All IKZF Family Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

JADA3 Related Classifications

HY-W450772 Related Classifications

Bioz

Keywords

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