JLJ648
JLJ648 is a Gag-Pol dimerizer with antiviral activity. JLJ648 can inhibit HIV replication and induce infected cell pyroptosis. JLJ648 can be used for the research of infection, such as HIV (human immunodeficiency virus).
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- 화학식: C23H17N3O3S
- 분자량:415.46
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
JLJ648 (3 days) inhibits HIV-1 replication in MT-2 cells with an EC50 of 1.6 nM[1].
JLJ648 shows low cytotoxicity in MT-2 and THP-1 cells (CC50>100 μM) and a CC50 of 22.9 μM in primary CD4+ T cells[1].
JLJ648 (17 h) promotes the homodimerization of recombinant HIV-1 RT p66 subunit with an EC50 of 95 nM[1].
JLJ648 (3-4 h) induces HIV protease-dependent pyroptosis in THP-1 clone14 cells and HIV-infected primary CD4+ T cells, with an EC50 of 86 nM[1].
JLJ648 (50 μM, 12 h) binds to HIV-1 RT p66 to form two oligomeric structures, subunits in catalytic/structural conformations and "infinity knot"-shaped homotetramer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 415.46
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화학식 C23H17N3O3S
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SMILES
S=C(N1)C=CN(CCOC2=C(OC3=CC=CC4=C3C=CC(C#N)=C4)C=CC=C2)C1=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JLJ648 Related Classifications
HY-178201 Related Classifications
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