country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-179469

Copy Link Print Information

KR-27452

KR-27452 is a selective and orally active PI4KIIIβ inhibitor with an IC₅₀ of 0.026 μM, while showing no activity against PI4KIIIα (IC₅₀ >10 μM) . KR-27452 specifically binds to and inhibits PI4KIIIβ, leading to reduced viral replication in cells. KR-27452 exhibits strong antiviral activity against human rhinovirus (RVs) and Coxsackievirus (COXs). KR-27452 can be used for the research of infection.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₄H₂₇N₃O₄S
분자량:453.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

KR-27452 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

PI4KIIIβ

0.026 μM (IC₅₀)

All PI4K Isoforms :

In Vitro

KR-27452 (Compound 2e) exhibits EC₅₀ of 0.236-0.813μM against RV-A and 0.104-0.664 μM against RV-B in H1HeLa cells, with CC₅₀ >100 μM and SI >123^[1].
KR-27452 has EC₅₀ of 0.118 μM against RV-C15 with SI >85 in HeLa-CDHR3 cells^[1].
KR-27452 shows EC₅₀ of 0.28-0.981μM against COX B1-B6 in H1HeLa cells, with CC₅₀ >100 μM and SI >102^[1].
KR-27452 (1-10 μM, 24 h) dose-dependently inhibits plaque formation in RV14-infected H1HeLa cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	Note	AUC	T_1/2	CL	T_max	F	V_{ss_obs}
Rat^[1]	5 mg/kg	i.v.	文献审核	1.8 μg·h/mL	6.41 h	2.82 L/h/kg	/	/	2.23 L/kg
Rat^[1]	10 mg/kg	p.o.	文献审核	1.44 μg·h/mL	4.2 h	1.62 μg/mL	0.42 h	52.4 %	/

Chemical Information

분자량 453.55
화학식 C₂₄H₂₇N₃O₄S
SMILES

O=C(N(CCCO)C)C1=CC(C2=C(C)N=C(NC(CC3=CC=CC=C3)=O)S2)=CC=C1OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ayele SA, et al. 2-amido-3-aryl-4-methyl-thiazole derivatives as broad-spectrum anti-rhinoviral agents. Eur J Med Chem. 2026;302(Pt 3):118318. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

KR-27452

All PI4K Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

KR-27452 Related Classifications

HY-179469 Related Classifications