Lergotrile
Lergotrile is a potent and orally active dopamine agonist and a prolactin secretion inhibitor. Lergotrile inhibits prolactin release from pituitaries by activating an adenohypophyseal dopamine receptor. Lergotrile has the potential for the research of Parkinson's disease.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 36945-03-6
- 화학식: C17H18ClN3
- 분자량:299.80
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Dopamine Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sympathetic neuron | ED50 |
0.27 μM/kg
Compound: 2
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Compound tested in vivo for sympathetic neuronal activity in cat cardioaccelerator nerve after iv administration
Compound tested in vivo for sympathetic neuronal activity in cat cardioaccelerator nerve after iv administration
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[PMID: 6699883] |
| Sympathetic neuron | ED50 |
0.27 μmol/Kg
Compound: 2
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Compound tested in vivo for sympathetic neuronal activity in cat cardioaccelerator nerve after iv administration
Compound tested in vivo for sympathetic neuronal activity in cat cardioaccelerator nerve after iv administration
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[PMID: 6699883] |
Chemical Information
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CAS No. 36945-03-6
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분자량 299.80
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화학식 C17H18ClN3
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SMILES
ClC1=C2C3=C(N1)C=CC=C3[C@]4([H])[C@@](N(C[C@@H](C4)CC#N)C)([H])C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Clemens JA, et al. Inhibition of prolactin secretion by lergotrile mesylate: mechanism of action. Acta Endocrinol (Copenh). 1975 Jun;79(2):230-7. [Content Brief]
[2]. Lemberger L, et al. The inhibitory effect of an ergoline derivative (lergotrile, compound 83636) on prolactin secretion in man. J Clin Endocrinol Metab. 1974 Sep;39(3):579-84. [Content Brief]
[3]. Lieberman A, et al. Treatment of Parkinson's disease with lergotrile mesylate. JAMA. 1977 Nov 28;238(22):2380-2. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lergotrile Related Classifications
HY-107002 Related Classifications
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