Liriopesides B
Based on 1 publication(s) in Google Scholar
Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects.
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- Purity: 99.92%
- CAS No.: 87425-34-1
- 화학식: C39H62O12
- 분자량:722.90
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보관:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Publications Citing Use of MedChemExpress (MCE) Liriopesides B
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Apoptosis Analysis
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Chemical Information
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CAS No. 87425-34-1
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Appearance Solid
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분자량 722.90
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화학식 C39H62O12
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Color White to light yellow
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SMILES
O[C@H]([C@H]([C@H]([C@@H](C)O1)O)O)[C@@H]1O[C@@H]2C[C@H](O[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)CC4=CCC5C6C[C@@]7(O[C@@]8(OC[C@@H](C)CC8)[C@@H](C)[C@@]7([C@]6(CCC5[C@@]24C)C)[H])[H]
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Synonyms
Nolinospiroside F
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Transl Cancer Res
Liriopesides B inhibits proliferation and metastasis and induces apoptosis of oral squamous cell carcinoma via the PI3K/Akt/mTOR signaling pathway. [Abstract]2025 Oct 31;14(10):6637-6652. PMID: 41234828
Liriopesides B purchased from MedChemExpress. Usage Cited in: Transl Cancer Res. 2025 Oct 31;14(10):6637-6652. [Abstract]
Liriopesides B (LPB) (12, 24 μM) induces apoptosis in SAS and CAL-27 cells.
Liriopesides B purchased from MedChemExpress. Usage Cited in: Transl Cancer Res. 2025 Oct 31;14(10):6637-6652. [Abstract]
The effect of Liriopesides B (LPB) (12, 24 μM) on the protein expression of PI3K, Akt, p-Akt, mTOR, p-mTOR, S6, p-S6, 4EBP1, and p-4EBP1 in SAS cells.
Liriopesides B purchased from MedChemExpress. Usage Cited in: Transl Cancer Res. 2025 Oct 31;14(10):6637-6652. [Abstract]
SC79 reverses the Liriopesides B (LPB) (12, 24 μM)-induced CAL-27 and SAS cells viability inhibition.
Liriopesides B purchased from MedChemExpress. Usage Cited in: Transl Cancer Res. 2025 Oct 31;14(10):6637-6652. [Abstract]
Liriopesides B (LPB) (12, 24 μM) inhibits the invasion ability of SAS and CAL-27 cells.
Liriopesides B purchased from MedChemExpress. Usage Cited in: Transl Cancer Res. 2025 Oct 31;14(10):6637-6652. [Abstract]
The effect of Liriopesides B (LPB) (5, 10 mg/kg) on tumor volume in SAS xenograft nude mice.
용액&용해도
DMSO : 100 mg/mL (138.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.46 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.46 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3833 mL | 6.9166 mL | 13.8332 mL | 34.5829 mL |
| 5 mM | 0.2767 mL | 1.3833 mL | 2.7666 mL | 6.9166 mL | |
| 10 mM | 0.1383 mL | 0.6917 mL | 1.3833 mL | 3.4583 mL | |
| 15 mM | 0.0922 mL | 0.4611 mL | 0.9222 mL | 2.3055 mL | |
| 20 mM | 0.0692 mL | 0.3458 mL | 0.6917 mL | 1.7291 mL | |
| 25 mM | 0.0553 mL | 0.2767 mL | 0.5533 mL | 1.3833 mL | |
| 30 mM | 0.0461 mL | 0.2306 mL | 0.4611 mL | 1.1528 mL | |
| 40 mM | 0.0346 mL | 0.1729 mL | 0.3458 mL | 0.8646 mL | |
| 50 mM | 0.0277 mL | 0.1383 mL | 0.2767 mL | 0.6917 mL | |
| 60 mM | 0.0231 mL | 0.1153 mL | 0.2306 mL | 0.5764 mL | |
| 80 mM | 0.0173 mL | 0.0865 mL | 0.1729 mL | 0.4323 mL | |
| 100 mM | 0.0138 mL | 0.0692 mL | 0.1383 mL | 0.3458 mL |
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