Lupulone
Based on 1 Customer Validation
Lupulone is a beta-acid from the hop plant H. lupulus with diverse biological activities including antibacterial, antioxidant, and anticarcinogenic properties.
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- Purity: 99.0%
- CAS No.: 468-28-0
- 화학식: C26H38O4
- 분자량:414.58
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
17 μM
Compound: 7
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Inhibition of LPS/IFN-gamma-induced NO production in mouse RAW264.7 cells after 16 hrs
Inhibition of LPS/IFN-gamma-induced NO production in mouse RAW264.7 cells after 16 hrs
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[PMID: 15679315] |
Chemical Information
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CAS No. 468-28-0
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Appearance Solid
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분자량 414.58
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화학식 C26H38O4
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Color White to off-white
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SMILES
O=C1C(C/C=C(C)\C)=C(C(C(CC(C)C)=O)=C(C1(C/C=C(C)\C)C/C=C(C)\C)O)O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 40 mg/mL (96.48 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Tagashira M, et al. Antioxidative activity of hop bitter acids and their analogues. Biosci Biotechnol Biochem. 1995 Apr;59(4):740-2. [Content Brief]
[2]. Lamy V, et al. Lupulone, a hop bitter acid, activates different death pathways involving apoptotic TRAIL-receptors, in human colon tumor cells and in their derived metastatic cells. Apoptosis 13(10), 1232-1242 (2008). [Content Brief]
[3]. Bocquet L, et al. Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei Strains. Molecules. 2019 Mar 14;24(6):102 [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4121 mL | 12.0604 mL | 24.1208 mL | 60.3020 mL |
| 5 mM | 0.4824 mL | 2.4121 mL | 4.8242 mL | 12.0604 mL | |
| 10 mM | 0.2412 mL | 1.2060 mL | 2.4121 mL | 6.0302 mL | |
| 15 mM | 0.1608 mL | 0.8040 mL | 1.6081 mL | 4.0201 mL | |
| 20 mM | 0.1206 mL | 0.6030 mL | 1.2060 mL | 3.0151 mL | |
| 25 mM | 0.0965 mL | 0.4824 mL | 0.9648 mL | 2.4121 mL | |
| 30 mM | 0.0804 mL | 0.4020 mL | 0.8040 mL | 2.0101 mL | |
| 40 mM | 0.0603 mL | 0.3015 mL | 0.6030 mL | 1.5075 mL | |
| 50 mM | 0.0482 mL | 0.2412 mL | 0.4824 mL | 1.2060 mL | |
| 60 mM | 0.0402 mL | 0.2010 mL | 0.4020 mL | 1.0050 mL | |
| 80 mM | 0.0302 mL | 0.1508 mL | 0.3015 mL | 0.7538 mL |
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