Mabuterol
Based on 1 Customer Validation
Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB.
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- Purity: 99.96%
- CAS No.: 56341-08-3
- 화학식: C13H18ClF3N2O
- 분자량:310.74
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Biological Activity
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Beta-2 adrenergic receptor |
Mabuterol (10-60 µM; 48 h) inhibits the proliferation of ASMCs induced by PDGF-BB[2].
Mabuterol (50 µM; 1h) suppresses the increase of intracellular Ca2+ induced by PDGF-BB (25 ng/ml)[2].
Mabuterol (50 µM; 48 h) significantly suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:rat ASMCs[2]
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Concentration:10, 20, 30, 40, 50, 60 µM
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Incubation Time:24, 48 h
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Result:Inhibited the proliferation of ASMCs induced by PDGF-BB (25 ng/ml) in a dose-dependent maner at 48 h.
Chemical Information
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CAS No. 56341-08-3
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Appearance Solid
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분자량 310.74
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화학식 C13H18ClF3N2O
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Color White to off-white
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SMILES
CC(NCC(O)C1=CC(C(F)(F)F)=C(N)C(Cl)=C1)(C)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : 125 mg/mL (402.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2181 mL | 16.0906 mL | 32.1812 mL | 80.4531 mL |
| 5 mM | 0.6436 mL | 3.2181 mL | 6.4362 mL | 16.0906 mL | |
| 10 mM | 0.3218 mL | 1.6091 mL | 3.2181 mL | 8.0453 mL | |
| 15 mM | 0.2145 mL | 1.0727 mL | 2.1454 mL | 5.3635 mL | |
| 20 mM | 0.1609 mL | 0.8045 mL | 1.6091 mL | 4.0227 mL | |
| 25 mM | 0.1287 mL | 0.6436 mL | 1.2872 mL | 3.2181 mL | |
| 30 mM | 0.1073 mL | 0.5364 mL | 1.0727 mL | 2.6818 mL | |
| 40 mM | 0.0805 mL | 0.4023 mL | 0.8045 mL | 2.0113 mL | |
| 50 mM | 0.0644 mL | 0.3218 mL | 0.6436 mL | 1.6091 mL | |
| 60 mM | 0.0536 mL | 0.2682 mL | 0.5364 mL | 1.3409 mL | |
| 80 mM | 0.0402 mL | 0.2011 mL | 0.4023 mL | 1.0057 mL | |
| 100 mM | 0.0322 mL | 0.1609 mL | 0.3218 mL | 0.8045 mL |
Mabuterol Related Classifications
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