MAX8

MAX8 (0.5 wt%) prepared at 37°C in DMEM forms a network of ~3 nm diameter fibrils, as visualized via negatively stained TEM^[1].
MAX8 hydrogel (0.5 wt%) encapsulation of 1 μg NGF does not change the physical gelation, shear-thinning, or rehealing properties of the hydrogel^[2].
MAX8 hydrogel (0.5 wt%; 7 days) released NGF remains biologically active, inducing neurite-like extension formation in PC12 cells over 7 days without media changes^[2].
MAX8 hydrogel (0.5 wt%; 3-7 days) direct contact does not inhibit NGF-induced neurite-like extension formation in PC12 cells, with 76% of cells forming extensions after 7 days^[2].
MAX8 hydrogel (0.5 wt%; 14-28 days) encapsulated NGF remains biologically active for at least 28 days, inducing neurite-like extension formation in 86% of PC12 cells, and MAX8 protects NGF/BDNF from degradation, maintaining stable release levels for at least 21 days compared to the ~3.4-3.5 day half-life of unencapsulated growth factors^[2].
MAX8 hydrogel (0.5 wt%; 24 hours) released NGF and BDNF remain biologically active, inducing proliferation in 3T3 fibroblasts and activating ERK signaling in PC12 cells^[2].
MAX8 (0.5-2 wt%; 1 hour at 20 °C post-gelation) shows that hydrogel stiffness increases linearly with peptide concentration, with plateau elastic moduli ranging from 270 Pa at 0.5 wt% to 3600 Pa at 2 wt%, while maintaining solid-like viscoelastic properties^[3].
MAX8 (1.0-1.5 wt%; 24 hours) hydrogels in pH 7.4, 150 mM NaCl D₂O buffer at 25°C have a fibril radius of ~1.5 nm and form a more heterogeneous, tightly meshed network with increased fibrillar branching (fractal dimension 1.6) compared to MAX1 hydrogels^[4].
MAX8 (0.5% (by weight); 4 h) forms ~3 nm-wide nanofibers consistent with a β-hairpin folded conformation^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.